Dihydrokaempferol
(Synonyms: 香橙素) 目录号 : GC38617
A flavone with diverse biological activities
Cas No.:480-20-6
Sample solution is provided at 25 µL, 10mM.
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Aromadendrin is a flavone that has been found in J. chinensis and has diverse biological activities.1,2,3,4 It scavenges DPPH radicals (IC50 = 2.21 ?M) and inhibits acetylcholinesterase (AChE; IC50 = 35.43 ?M), but not butyrylcholinesterase (BChE) and β-secretase 1 (BACE1; IC50s = >200 ?M), in cell-free assays.1,2 Aromadendrin inhibits the growth of BT474 breast, ChaGo-K-1 lung, HepG2 liver, KATO III gastric, and SW620 colon cancer cells (IC50s = 11.66, 12.32, 13.67, 39.79, and 41.11 ?M, respectively).1 It prevents cytokine production in anti-CD3 and anti-CD28-stimulated T cells in a concentration-dependent manner.3 Aromadendrin reduces pancreatic damage in a mouse model of caerulin and LPS-induced severe acute pancreatitis in a dose-dependent manner.4
1.Chunhakant, S., and Chaicharoenpong, C.Antityrosinase, antioxidant, and cytotoxic activities of phytochemical constituents from Manilkara zapota L. barkMolecules24(15)2798(2019) 2.Jung, H.J., Jung, H.A., Min, B.-S., et al.Anticholinesterase and β-site amyloid precursor protein cleaving enzyme 1 inhibitory compounds from the heartwood of Juniperus chinensisChem. Pharm. Bull. (Tokyo)63(11)955-960(2015) 3.Lee, H.-S., and Jeong, G.-S.Aromadendrin inhibits T cell activation via regulation of calcium influx and NFAT activityMolecules25(19)4590(2020) 4.Liang, X., Hu, C., Liu, C., et al.Dihydrokaempferol (DHK) ameliorates severe acute pancreatitis (SAP) via Keap1/Nrf2 pathwayLife Sci.261118340(2020)
| Cas No. | 480-20-6 | SDF | |
| 别名 | 香橙素 | ||
| Canonical SMILES | O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC=C(O)C=C3)[C@H]1O | ||
| 分子式 | C15H12O6 | 分子量 | 288.25 |
| 溶解度 | DMSO: 10 mM | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4692 mL | 17.3461 mL | 34.6921 mL |
| 5 mM | 0.6938 mL | 3.4692 mL | 6.9384 mL |
| 10 mM | 0.3469 mL | 1.7346 mL | 3.4692 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet