Cedrol

(+)-Cedrol is a sesquiterpene alcohol that has been used in Cannabis testing and has diverse biological activities.¹ It inhibits the growth of L. sulphureus, G. trabeum, L. betulina, and T. versicolor wood decay fungi when used at a concentration of 100 μg/ml.² (+)-Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (K_is = 0.9 and 3.4 μM, respectively).³ In vivo, (+)-cedrol (200 mg/kg) prevents hair follicle dystrophy and reduces hair loss in a mouse model of alopecia induced by cyclophosphamide .⁴ (+)-Cedrol-loaded nanostructured lipid particles reduce peritoneal mast cell degranulation, a component of the type I anaphylactic response, induced by compound 48/80 in mice.⁵

1.Fischedick, J.T.Identification of terpenoid chemotypes among high (–)-trans-Δ9-tetrahydrocannabinol-producing Cannabis sativa L. cultivarsCannabis Cannabinoid Res.2(1)34-47(2017) 2.Cheng, S.S., Chung, M.J., Lin, C.Y., et al.Phytochemicals from Cunninghamia konishii Hayata act as antifungal agentsJ. Agric. Food Chem.60(1)124-128(2012) 3.Jeong, H.U., Kwon, S.S., Kong, T.Y., et al.Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomesJ. Toxicol. Environ. Health A77(22-24)1522-1532(2014) 4.Chen, S.S., Zhang, Y., Lu, Q.L., et al.Preventive effects of cedrol against alopecia in cyclophosphamide-treated miceEnviron. Toxicol. Pharmacol.46270-276(2016) 5.Chakraborty, S., Kar, N., Kumari, L., et al.Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in miceInt. J. Nanomedicine124849-4868(2017)