Dimethyl phthalate
(Synonyms: 邻苯二甲酸二甲酯) 目录号 : GC38701
Dimethyl phthalate is an organic compound, used as an insect repellent for mosquitoes and flies.
Cas No.:131-11-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Dimethyl phthalate is an organic compound, used as an insect repellent for mosquitoes and flies.
| Cas No. | 131-11-3 | SDF | |
| 别名 | 邻苯二甲酸二甲酯 | ||
| Canonical SMILES | O=C(C1=CC=CC=C1C(OC)=O)OC | ||
| 分子式 | C10H10O4 | 分子量 | 194.18 |
| 溶解度 | DMSO : 100mg/mL | 储存条件 | Store at -20°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.1499 mL | 25.7493 mL | 51.4986 mL |
| 5 mM | 1.03 mL | 5.1499 mL | 10.2997 mL |
| 10 mM | 0.515 mL | 2.5749 mL | 5.1499 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Dimethyl phthalate induces blood immunotoxicity through oxidative damage and caspase-dependent apoptosis
Sci Total Environ 2022 Sep 10;838(Pt 2):156047.PMID:35598668DOI:10.1016/j.scitotenv.2022.156047.
Dimethyl phthalate (DMP), a low-molecular-weight phthalate ester, exists in ectoparasiticides, plastics, and insect repellants, and has been linked to neurotoxic, reproductive, and endocrine disruptive responses. However, its blood immunotoxic effects and mechanism are still poorly understood. In this study, rats were exposed to gradient concentrations of DMP through intragastric administration to assess the blood immunotoxic effects in the combined assay of biomarker, cytometry, and transcriptomics. DMP treatment altered the redox status of rats, thus causing oxidative damage. Significantly decreased blood cell counts and disordered antibody and cytokine secretion were observed in treated rats, suggesting the suppressed immune defense and destructed inflammatory regulation. Flow cytometry showed that in lymphocytes, especially CD3+CD4+ T cells, the occurrence of apoptosis/necrosis was positively related to DMP exposure level. Transcriptomics revealed an oxidative stress-related mechanism. The overexpression of the Bcl-2 family genes and the activation of the Fas/FasL pathway triggered downstream caspase cascade and caused reactive oxygen species signaling-mediated apoptosis/necrosis. To the best of our knowledge, it was the first report that the exposure to low-molecular-weight phthalate esters potentially triggered blood immunotoxicity. The result and underlying mechanisms can provide an essential basis for understanding phthalate ester toxicity and usage regulation.
Dimethyl phthalate destroys the cell membrane structural integrity of Pseudomonas fluorescens
Front Microbiol 2022 Aug 22;13:949590.PMID:36071970DOI:10.3389/fmicb.2022.949590.
A Gram-negative bacteria (Pseudomonas fluorescens) was exposed to different concentrations (0, 20, and 40 mg/L) of Dimethyl phthalate (DMP) for 8 h, and then Fourier transform infrared spectroscopy (FTIR) analysis, lipopolysaccharide content detection, analysis of fatty acids, calcein release test, proteomics, non-targeted metabolomics, and enzyme activity assays were used to evaluate the toxicological effect of DMP on P. fluorescens. The results showed that DMP exposure caused an increase in the unsaturated fatty acid/saturated fatty acid (UFA/SFA) ratio and in the release of lipopolysaccharides (LPSs) from the cell outer membrane (OM) of P. fluorescens. Moreover, DMP regulated the abundances of phosphatidyl ethanolamine (PE) and phosphatidyl glycerol (PG) of P. fluorescens and induced dye leakage from an artificial membrane. Additionally, excessive reactive oxygen species (ROS), malondialdehyde (MDA), and changes in antioxidant enzymes (i.e., catalase [CAT] and superoxide dismutase [SOD]) activities, as well as the inhibition of Ca2+-Mg2+-ATPase and Na+/K+-ATPase activities in P. fluorescens, which were induced by the DMP. In summary, DMP could disrupt the lipid asymmetry of the outer membrane, increase the fluidity of the cell membrane, and destroy the integrity of the cell membrane of P. fluorescens through lipid peroxidation, oxidative stress, and ion imbalance.
Catalytic oxidation of Dimethyl phthalate over titania-supported noble metal catalysts
J Hazard Mater 2021 Jan 5;401:123274.PMID:32763674DOI:10.1016/j.jhazmat.2020.123274.
Semi-volatile organic compounds (SVOCs) are organic compounds with the boiling point ranging between 240/260 ℃ and 380/400 ℃. Detailed knowledge regarding catalytic removal of SVOCs from indoor environment is very limited as it remains challenge to explore such reaction due to the viscosity nature of target contaminants. Here, we established a facile methodology to explore the heterogeneous catalytic oxidation reaction of Dimethyl phthalate (DMP), a model SVOC, over the surface of supported catalyst. DMP was found to be gradually oxidized over the surface of titania supported catalysts including palladium (Pd), platinum and ruthenium with increasing temperature. The cleavage of side chain of DMP occurs at 75 ℃ over the surface of Pd/TiO2, which is significantly lower than that of the other two catalysts. Carbon dioxide was observed as the main product of the catalytic oxidation reaction. However, aromatic products and small molecule products were still observed as side-product in different temperature range. Density functional theory calculations further show that DMP can react with reactive oxygen species to form phthalic acid. While the cleavage of the DMP side chain occurs to form products such as methyl benzoate. This work thus provides basic knowledge about indoor SVOCs catalytic oxidation removal.
Dimethyl phthalate damaged the cell membrane of Escherichia coli K12
Ecotoxicol Environ Saf 2019 Sep 30;180:208-214.PMID:31096126DOI:10.1016/j.ecoenv.2019.05.009.
Dimethyl phthalate (DMP), a phthalate ester (PAE), is a ubiquitous and organic pollutant. In this study, the toxicity of DMP to Escherichia coli K12 and its underlying mechanism were investigated. The results showed that DMP inhibited the growth of E. coli K12 and induced cell inactivation and/or death. DMP caused serious damage to the cell membrane of E. coli K12, and the damage increased with higher DMP concentrations. DMP exposure disrupted cell membranes, as evidenced by dose-dependent variations of cell structures, surface properties, and membrane compositions. Increases in the malondialdehyde (MDA) content indicated an increase in oxidative stress induced by DMP in E. coli K12. The activity of succinic dehydrogenase (SDH) was changed by DMP, which could affect energy metabolism in the membrane of E. coli K12. The expression levels of OmpA and OmpX were increased, and the expression levels of OmpF and OmpW were decreased, in E. coli K12 exposed to DMP. The toxicities of DMP to E. coli K12 could be ascribed to membrane disruption and oxidative stress-induced cell inactivation and/or death. The outcomes will shed new light on the assessment of the ecological effects of DMP.
Degradation of Dimethyl phthalate through Fe(II)/peroxymonosulphate heightened by fulvic acid: efficiency and possible mechanism
Environ Technol 2022 Feb 3;1-13.PMID:34873993DOI:10.1080/09593330.2021.2014576.
Ferrous iron (Fe(II)) reacts with peroxymonosulphate (PMS) to form active oxidants that can degrade refractory organic pollutants. However, the conversion rate of Fe(III) to Fe(II) is slow, which limits its actual application. In the study, the effect of fulvic acid (FA) on the degradation of Dimethyl phthalate (DMP) by Fe(II)/PMS was investigated. Moreover, the degradation process of DMP was predicted by the preliminary identification of active free radicals and intermediates. As expected, FA gave rise to a higher concentration of Fe(II) than that in Fe(II)/PMS to enhance the removal of DMP in Fe(II)/PMS system. The precipitate, involved in FA and iron, was an important composite to promote the degradation of DMP in the system. Also, the response surface methodology (RSM) was applied to model and optimize the degradation conditions of DMP. The highest removal efficiency (85.70%) was obtained at pH = 3.86, [PMS] = 0.96 mM, [FA] = 11.44 mg/L and [DMP] = 5 µM. The results of free radical quenching experiments and EPR showed that •OH and SO4•- were the main active radicals in this system. The degradation intermediates of DMP were monomethyl phthalate (MMP), phthalic acid and benzoic acid. Discoveries of this study had raised the current understanding of the application of FA keeping the cycles of Fe(II)/Fe(III) for peroxymonosulphate activation, which could afford valuable information for the degradation of organic pollutants by FA/Fe(II)/PMS.