Home>>Lipids>> Glycerolipids>>1,2-Dilinoleoyl-3-Oleoyl-rac-glycerol

1,2-Dilinoleoyl-3-Oleoyl-rac-glycerol

(Synonyms: 1,2-二亚油酰-3-油酰反式甘油,1,2-Dilinolein-3-Olein) 目录号 : GC45288

A triacylglycerol

1,2-Dilinoleoyl-3-Oleoyl-rac-glycerol Chemical Structure

Cas No.:2190-21-8

规格 价格 库存 购买数量
10mg
¥770.00
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25mg
¥1,542.00
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50mg
¥2,502.00
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100mg
¥4,625.00
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产品描述

1,2-Dilinoleoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains linoleic acid at the sn-1 and sn-2 positions and oleic acid at the sn-3 position. It has been found in ostrich and emu oils, as well as in the fat body of male B. lapidarius bumblebees.[1],[2] 1,2-Dilinoleoyl-3-oleoyl-rac-glycerol (3% w/v) reduces scald development on apples of the Delicious variety when applied immediately following harvest and assessed after six months of storage.[3]

References
[1]. Zhou, Y., Xue, Y., Chen, G.C., et al. Rapid separation and characterisation of triacylglycerols in ostrich oil by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Food Chem. 141(3), 2098-2102 (2013).
[2]. Cva•ka, J., Hovorka, O., Jiro•, P., et al. Analysis of triacylglycerols in fat body of bumblebees by chromatographic methods. J. Chromatogr. A. 1101(1-2), 226-237 (2006).
[3]. Ju, Z., Duan, Y., and Ju, Z. Mono-, di-, and tri-acylglycerols and phospholipids from plant oils inhibit scald development in ’Delicious’ apples. Postharvest Bio. Technol. 19(1), 1-7 (2000).

Chemical Properties

Cas No. 2190-21-8 SDF
别名 1,2-二亚油酰-3-油酰反式甘油,1,2-Dilinolein-3-Olein
化学名 (9Z,12Z)-9,12-octadecadienoic acid, 1,1'-[1-[[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]methyl]-1,2-ethanediyl] ester
Canonical SMILES O=C(CCCCCCC/C=C\C/C=C\CCCCC)OCC(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
分子式 C57H100O6 分子量 881.4
溶解度 Slightly soluble in methanol 储存条件 Store at -20°C
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1 mM 1.1346 mL 5.6728 mL 11.3456 mL
5 mM 0.2269 mL 1.1346 mL 2.2691 mL
10 mM 0.1135 mL 0.5673 mL 1.1346 mL
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Research Update

Research on the effect of spleen-invigorating and anti-swelling active ingredients in crude and processed coix seed based on Spectrum - Effects relationship combined with chemometrics

J Pharm Biomed Anal 2021 Oct 25;205:114350.PMID:34507270DOI:10.1016/j.jpba.2021.114350

Coix seed (CS) is the dry mature seed kernel of Coix lacrma-jobi L. var. mayuen (Roman.) Stapf, which has the effect of spleen-invigorating and anti-swelling. However, research reports on the main active ingredients of CS were minimal. The purpose of this study was to find the main active ingredients that affect the efficacy of CS to invigorate the spleen and reduce swelling through the spectrum-effect relationship, combined with chemometrics, grey relational analysis (GRA) and entropy method, and to compare the differences between the effects of crude and processed CS. First of all, the HPLC-ELSD method was used to establish the chromatographic fingerprint of CS, and 12 batches of CS samples were analyzed through chemometrics in this study. Then, we studied the effect of spleen-invigorating and anti-swelling in CS. Finally, through grey relational analysis and entropy method, the spectrum-effect relationship between the chromatographic fingerprint and the seven pharmacodynamic effect indexes was studied. The results showed that the main pharmacologically active ingredients were 1,3-Dioleoyl-2-palmitoylglycerol (peak 8), 1,2-Dilinoleoyl-3-Oleoyl-rac-glycerol (peak 2), 1,3-Dipalmitoyl-2-Linolein (peak 5), 1,2-Dilinoleoyl-3-palmitoyl-rac-glycerol (peak 3), 1,2-Dioleoyl-3-linoleoyl-rac-glycerol (peak 4), and glycerol trioleate (peak 7), and the comprehensive efficacy of bran-fried CS was better than that of raw CS. In summary, we have identified the main active ingredients related to the efficacy of CS. As far as we know, this is the first time that the crude and processed CS spectrum-effect relationship has been established and compared, which provides a theoretical basis for subsequent studies on the material basis and molecular mechanism of CS pharmacodynamics.