4-Chloromethamphetamine (hydrochloride)
(Synonyms: 4-CMA, p-CMA, para-CMA, Ro 4-6861) 目录号 : GC45342
An Analytical Reference Standard
Cas No.:30572-91-9
Sample solution is provided at 25 µL, 10mM.
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Methamphetamine is a regulated psychoactive compound that is both neurotoxic and prone to addiction.1,2,3 4-Chloromethamphetamine is a halogenated analog of methamphetamine. In vivo, it is converted to 4-chloroamphetamine , which causes rapid depletion of neurological serotonin within hours after injection.4,5 4-Chloroampetamine is highly and selectively neurotoxic, targeting serotonergic neurons.4,5 This product is intended for forensic and research applications.
References
1. Rothman, R.B., Baumann, M.H., Dersch, C.M., et al. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Science 39(1), 32-41 (2001).
2. Rothman, R.B., Vu, N., Partilla, J.S., et al. In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. J. Pharmacol. Exp. Ther. 307(1), 138-145 (2003).
3. Jirovsky, D., Lemr, K., SevcÍk, J., et al. Methamphetamine - properties and analytical methods of enantiomer determination. Forensic Sci. Int. 96(1), 61-70 (1998).
4. Fuller, R.W., Baker, J.C., Perry, K.W., et al. Comparison of 4-chloro-, 4-bromo- and 4-fluoroamphetamine in rats: Drug levels in brain and effects on brain serotonin metabolism. Neuropharmacology 14(10), 739-746 (1975).
5. Harvey, J.A., McMaster, S.E., and Fuller, R.W. Comparison between the neurotoxic and serotonin-depleting effects of various halogenated derivatives of amphetamine in the rat. Journal of Pharmacology and Experimental Therapeutics 202(3), 581-589 (1977).
| Cas No. | 30572-91-9 | SDF | |
| 别名 | 4-CMA, p-CMA, para-CMA, Ro 4-6861 | ||
| Canonical SMILES | CC(NC)CC1=CC=C(Cl)C=C1.Cl | ||
| 分子式 | C10H14ClN.HCl | 分子量 | 220.1 |
| 溶解度 | DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.5434 mL | 22.7169 mL | 45.4339 mL |
| 5 mM | 0.9087 mL | 4.5434 mL | 9.0868 mL |
| 10 mM | 0.4543 mL | 2.2717 mL | 4.5434 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet