9-Hydroxyellipticine (hydrochloride)
(Synonyms: 9-OH-Ellipticine, NSC 210717) 目录号 : GC45367
An ellipticine derivative with diverse biological activities
Cas No.:52238-35-4
Sample solution is provided at 25 µL, 10mM.
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9-Hydroxyellipticine is a derivative of ellipticine with diverse biological activities.1,2,3 It inhibits aroclor-induced activation of aniline hydroxylase, aminopyrine N-demethylase, and 7-ethoxycourmarin O-deethylase in rat liver microsomes (Kis = 3.5, 0.6, and 0.74 μM, respectively).1 9-Hydroxyellipticine inhibits the growth of L1210 murine leukemia cells (IC50 = 3 nM) in vitro and increases survival in an L1210 mouse leukemia model.2,3 It inhibits carrageenan-induced edema and UV-induced erythema in guinea pigs.4
References
1. Lesca, P., Rafidinarivo, E., Lecointe, P., et al. A class of strong inhibitors of microsomal monooxygenases: The ellipticines. Chem. Biol. Interact. 24(2), 189-197 (1979).
2. Monnot, M., Mauffret, O., Simon, V., et al. DNA-drug recognition and effects on topoisomerase II-mediated cytotoxicity. A three-mode binding model for ellipticine derivatives. J. Biol. Chem. 266(3), 1820-1829 (1991).
3. Le Pecq, J.B., Grosse, C., Dat-Xuong, N., et al. Antitumor activity of 9-hydroxyellipticine (NSC 210717) ON L1210 mouse leukemia and the effect of route of injection. Cancer Res. 36(9 pt. 1), 3067-3076 (1976).
4. Cros, J., Thibault, A., and Dat-Xuong, N. Anti-inflammatory effect of hydroxy-9-ellipticine. C. R. Acad. Sci. Hebd. Seances Acad. Sci. D. 281(15), 1139-1142 (1975).
| Cas No. | 52238-35-4 | SDF | |
| 别名 | 9-OH-Ellipticine, NSC 210717 | ||
| Canonical SMILES | CC1=C2C(NC3=C2C=C(O)C=C3)=C(C)C4=C1C=NC=C4.Cl | ||
| 分子式 | C17H14N2O.HCl | 分子量 | 298.8 |
| 溶解度 | DMSO: slightly, heated,Methanol: slightly | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.3467 mL | 16.7336 mL | 33.4672 mL |
| 5 mM | 0.6693 mL | 3.3467 mL | 6.6934 mL |
| 10 mM | 0.3347 mL | 1.6734 mL | 3.3467 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet