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Histone H3K9Me3 (3-17) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) Sale

(Synonyms: H-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Me3)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-OH, H3K9me3, Histone H3 (3-17) (Lys9me3), Lys(Me3)9-Histone H3 (3-17), TKQTAR-K(Me3)-STGGKAPR) 目录号 : GC45484

A peptide fragment of histone H3

Histone H3K9Me3 (3-17) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) Chemical Structure

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1mg
¥4,266.00
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Sample solution is provided at 25 µL, 10mM.

Description

Histone H3K9Me3 (3-17) is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 4-18 of the human histone H3 sequence. Trimethylation of histone H3 at lysine 9 is associated with gene repression, prevents transcription factor binding, and is a target of the heterochromatin protein 1 (HP1) family proteins CBX1, CBX3, and CBX5.1,2 It is recognized by the plant homeodomain fingers of chromodomain helicase DNA binding protein 4 (CHD4), a member of the NuRD deacetylase complex that is upregulated in a variety of cancers and implicated in the DNA damage response.3

References
1. Kaustov, L., Ouyang, H., Amaya, M., et al. Recognition and specificity determinants of the human Cbx chromodomains. J. Biol. Chem. 286(1), 521-529 (2011).
2. Becker, J.S., Nicetto, D., and Zaret, K.S. H3K9me3-dependent heterochromatin: Barrier to cell fate changes. Trends Genet. 32(1), 29-41 (2016).
3. Mansfield, R.E., Musselman, C.A., Kwan, A.H., et al. Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9. J. Biol. Chem. 286(13), 11779-11791 (2011).

化学性质

Cas No. SDF
别名 H-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Me3)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-OH, H3K9me3, Histone H3 (3-17) (Lys9me3), Lys(Me3)9-Histone H3 (3-17), TKQTAR-K(Me3)-STGGKAPR
Canonical SMILES CC(C)C1=C(O)C=C(C)C(O)=C1
分子式 C68H125N25O21.XCF3COOH 分子量 1628.9
溶解度 Water: 1 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.6139 mL 3.0696 mL 6.1391 mL
5 mM 0.1228 mL 0.6139 mL 1.2278 mL
10 mM 0.0614 mL 0.307 mL 0.6139 mL
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