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Prostaglandin Bx Sale

(Synonyms: PGBx) 目录号 : GC45551

A mixture of PGB1 oligomers with antioxidant and anti-inflammatory activity

Prostaglandin Bx Chemical Structure

Cas No.:39306-29-1

规格 价格 库存 购买数量
500μg
¥411.00
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1mg
¥789.00
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5mg
¥3,289.00
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10mg
¥5,756.00
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Sample solution is provided at 25 µL, 10mM.

Description

PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytoprotective activity which may be attributed to inhibition of the 14 kDa sPLA2.2,3 At a dose of 1 mg/kg, PGBx significantly reduces the incidence of ulcers in rats.2

References
1. Polis, B.D., Polis, E., and Kwong, S. Protection and reactivation of oxidative phosphorylation in mitochondria by a stable free-radical prostaglandin polymer (PGBΧ). Proceedings of the National Academy of Sciences of the United States of America 76, 1598-1602 (1979).
2. Kumashiro, R., Devlin, T.M., Kholoussy, A.M., et al. Prostaglandin BΧ in the prevention of stress ulcers in rats. International Surgery 70, 247-250 (1985).
3. Franson, R.C., Rosenthal, M.D., and Regelson, W. Mechanism(s) of cytoprotective and anti-inflammatory activity of PGB1 oligomers: PGBx has potent anti-phospholipase A2 and anti-oxidant activity. Prostaglandins, Leukotrienes and Essential Fatty Acids 43, 63-70 (1991).

化学性质

Cas No. 39306-29-1 SDF
别名 PGBx
Canonical SMILES CN(C)[C@@H](C1=CC=CC=C1)[C@H](C)NC(C2=CC=CC=C23)=NN4C3=NN=C4C.Cl.Cl
分子式 (PGB)nn=3-5 分子量 1
溶解度 DMF: >100 mg/ml,DMSO: >100 mg/ml,Ethanol: >100 mg/ml,PBS pH 7.2: 3.8 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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