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Semax Sale

(Synonyms: 脑力肽) 目录号 : GC45565

A synthetic peptide with neuroprotective, analgesic, and anxiolytic properties

Semax Chemical Structure

Cas No.:80714-61-0

规格 价格 库存 购买数量
1mg
¥2,141.00
现货
5mg
¥8,034.00
现货
10mg
¥13,928.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) (4-10) that has neuroprotective, analgesic, and anxiolytic properties.1,2,3 In vivo, semax (0.3 mg/kg) reduces cortical nitric oxide (NO) production and the number of neurological disturbances, such as seizures, falling, and twisting, in a rat model of global ischemia.1 It decreases acetic acid-induced writhing and nociception in a hind paw compression test in mice when administered at doses ranging from 0.015 to 0.5 mg/kg.2 Semax also increases time spent in the open arms in the elevated plus maze, indicating anxiolytic activity, in a rat model of maternal deprivation-induced anxiety.3

References
1. Bashkatova, V.G., Koshelev, V.B., Fadyukova, O.E., et al. Novel synthetic analogue of ACTH 4-10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia. Brain Res. 894(1), 145-149 (2001).
2. Ivanova, D.M., Levitskaya, N.G., Andreeva, L.A., et al. Comparative study of analgesic potency of ACTH4-10 fragment and its analog semax. Bull. Exp. Biol. Med. 143(1), 5-8 (2007).
3. Volodina, M.A., Sebentsova, E.A., Glazova, N.Y., et al. Semax attenuates the influence of neonatal maternal deprivation on the behavior of adolescent white rats. Bull. Exp. Biol. Med. 152(5), 560-563 (2012).

化学性质

Cas No. 80714-61-0 SDF
别名 脑力肽
Canonical SMILES OC([C@H]1N(C(CNC([C@H]2N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCSC)=O)CCC(O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)CCC2)=O)=O)CCC1)=O
分子式 C37H51N9O10S 分子量 813.9
溶解度 DMF: 1mg/mL,DMSO: 5mg/mL,PBS (pH 7.2): 10mg/mL 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.2287 mL 6.1433 mL 12.2865 mL
5 mM 0.2457 mL 1.2287 mL 2.4573 mL
10 mM 0.1229 mL 0.6143 mL 1.2287 mL
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