Stearic Acid-d35
(Synonyms: 氘代十八烷酸(D35)) 目录号 : GC45569An internal standard for the quantification of stearic acid
Cas No.:17660-51-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Stearic acid-d35 is intended for use as an internal standard for the quantification of stearic acid by GC- or LC-MS. Stearic acid is a long-chain saturated fatty acid. It is a major component of cocoa butter and has also been found in beef fat and vegetable oils.1,2,3 Unlike many long-chain saturated fatty acids, dietary stearic acid does not induce hypercholesterolemia or raise LDL-cholesterol.4
References
1. Chuparova, E., Chobanov, D., and Popov, A. Quantitative analysis of fatty acids by liquid-partition chromatography. Izv. Inst. Org. Khim. Bulgar. Akad. Nauk 2, 31-35 (1965).
2. Westerling, D.B., and Hedrick, H.B. Fatty acid composition of bovine lipids as influenced by diet, sex and anatomical location and relationship to sensory characteristics. J. Anim. Sci. 48(6), 1343-1348 (1979).
3. Demirba•, A. Chemical and fuel properties of seventeen vegetable oils. Energy Sources 25(7), 721-728 (2003).
4. Grundy, S.M. Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids. Am. J. Clin. Nutr. 60(Suppl 6), 986S-990S (1994).
| Cas No. | 17660-51-4 | SDF | |
| 别名 | 氘代十八烷酸(D35) | ||
| Canonical SMILES | [2H]C([2H])(C(O)=O)C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H] | ||
| 分子式 | C18HD35O2 | 分子量 | 319.7 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 20 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.1279 mL | 15.6397 mL | 31.2793 mL |
| 5 mM | 0.6256 mL | 3.1279 mL | 6.2559 mL |
| 10 mM | 0.3128 mL | 1.564 mL | 3.1279 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Raman studies of the C-H and C-D stretching regions in stearic acid and some specifically deuterated derivatives
Chem Phys Lipids 1976 Nov;17(4):456-65.PMID:991393DOI:10.1016/0009-3084(76)90047-5.
Raman spectra of polycrystalline stearic acid-do, Stearic Acid-d35, 16:16-d2-18:18:18-d3-stearic acid, 18:18:18-d3-stearic acid, 17:17-d2-stearic acid, 17-d1-stearic acid, 16:16-d2-stearic acid, 12:12-d2-stearic acid and 12-d1-stearic acid have been obtained for the region containing the C-D and C-H stretching vibrations. Assignments of the methyl, methyl-d3, methylene, methylene-d2 and methylene-d1 stretching vibrations are discussed.
Kinetic evidence suggests spinodal phase separation in stratum corneum models by IR spectroscopy
J Phys Chem B 2014 Apr 24;118(16):4378-87.PMID:24702264DOI:10.1021/jp501003c.
Although lipid structure in models for the stratum corneum (SC), the main barrier to skin permeability, has been extensively studied, only limited data are extant concerning the kinetic mechanism for the formation of domains, lamellar phases, and lipid packing motifs. Such information would be of substantial interest in the characterization of the effects of disease states which disrupt the barrier. Kinetic IR spectroscopy measurements probed the temporal sequence of molecular events producing ordered structures in a three-component SC model of equimolar ceramide[NS] (cer[NS]), perdeuterated Stearic Acid-d35 (SA-d35), and cholesterol. Samples, heated above Tm, were quenched to 31 °C, and then spectra were recorded at ∼15 min intervals for a total of 20-150 h. IR provides unique molecular structure information about headgroup H-bonding, lipid packing, and lipid chain order. The following sequence for phase separation was observed: (1) Formation of ceramide amide H-bonds from disordered forms to ordered structures (0.5-4 h); (2) appearance of ordered ceramide chains with some orthorhombically packed structures (0.5-8 h); and (3) phase separation of large orthorhombic domains of SA-d35 (4-10 h). A spinodal decomposition mechanism, defined by continuous composition changes during the phase separation, suggests a qualitative description for these events.
Deuterated fatty acids as Raman spectroscopic probes of membrane structure
Biochim Biophys Acta 1976 Sep 7;443(3):613-7.PMID:963072DOI:10.1016/0005-2736(76)90480-6.
Raman spectra are reported for the C-D stretching region of Stearic Acid-d35 bound in egg lecithin multilayers. The temperature dependence of the spectra shows that the linewidth of the C-D stretching bands is a sensitive and non-perturbative probe of membrane hydrocarbon chain conformation. The utility of this approach for studying lipid conformation in membranes containing a significant fraction of non-lipid component is discussed.
Raman spectral conformational order indicators in perdeuterated alkyl chain systems
J Phys Chem A 2006 Dec 28;110(51):13744-53.PMID:17181330DOI:10.1021/jp0655219.
Conformational order indicators for perdeuterated alkyl chain systems are identified in the Raman spectra of nonadecane-d40, polyethylene-d4, and Stearic Acid-d35. Six spectral indicators are identified: I[nu(a)(CD2)2196]/I[nu(a)(CD2)2172], I[nu(C-C)G]/I[nu(C-C)T], I[nu(s)(CD3)]/I[nu(a)(CD2)2172], I[nu(s)(CD2)]/I[nu(a)(CD2)2172], and the full width at half-maximum (fwhm) and frequency of the nu(s)(CD2) mode. Among these indicators, the ratio of I[nu(a)(CD2)2196]/I[nu(a)(CD2)2172] is considered a primary indicator of conformational order, since it responds to alkyl chain conformational changes in a manner similar to the I[nu(a)(CH2)]/I[nu(s)(CH2)] primary indicator for hydrogenated systems. Other indicators are correlated to this primary indicator to derive a better understanding of the effect of structural attributes on conformational order in perdeuterated alkyl chain systems. These Raman spectral order indicators are applicable to any perdeuterated alkyl-containing system including lipids, biological membranes, alkylsilane-based chromatographic stationary phases, and self-assembled monolayers.