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Virustomycin A Sale

(Synonyms: AM 2604A) 目录号 : GC45594

A macrolide antibiotic

Virustomycin A Chemical Structure

Cas No.:84777-85-5

规格 价格 库存 购买数量
500μg
¥942.00
现货
1mg
¥1,696.00
现货
5mg
¥6,595.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Virustomycin A is a macrolide antibiotic originally isolated from Streptomyces.1,2 It is active against infectious and plant pathogenic fungi, including T. vaginalis and P. oryzae (MICs = 6.25 and 12.5 μg/ml, respectively), as well as the parasite T. foetus (MIC = 25 μg/ml).1 It also decreases plaque formation by RNA and DNA viruses (ED50 = 0.0003 μg/ml for all). Virustomycin A is active against the GUTat 3.1 strain of T. brucei brucei, but not the STIB900 strain of T. brucei rhodesiense (IC50s = 0.45 and 480 ng/ml, respectively), and induces cytotoxicity in human MRC-5 cells with an IC50 value of 80 ng/ml.3 It inhibits RNA, DNA, and protein synthesis in T. foetus.2

References
1. Omura, S., Shimizu, H., Iwai, Y., et al. AM-2604 A, a new antiviral antibiotic produced by a strain of Streptomyces. J. Antibiot. (Tokyo) 35(12), 1632-1637 (1982).
2. Omura, S., Otogguro, K., and Tanaka, H. The mode of action of a novel 18-membered macrolide, virustomycin A (AM-2604 A), on Trichomonas foetus. J. Antibiot. (Tokyo) 36(12), 1755-1761 (1983).
3. Otoguro, K., Ishiyama, A., Namatame, M., et al. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. J.Antibiot.(Tokyo) 61(6), 372-378 (2008).

化学性质

Cas No. 84777-85-5 SDF
别名 AM 2604A
Canonical SMILES O=C1O[C@H]([C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](OC(/C=C/C(NC3=C(O)CCC3=O)=O)=O)[C@H](C)[C@@H](/C=C\C)O2)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)\C=C1\OC
分子式 C48H71NO14 分子量 886.1
溶解度 Chloroform: soluble,Ethanol: soluble,Methanol: soluble 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.1285 mL 5.6427 mL 11.2854 mL
5 mM 0.2257 mL 1.1285 mL 2.2571 mL
10 mM 0.1129 mL 0.5643 mL 1.1285 mL
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