α-Linolenic Acid ethyl ester-d5
(Synonyms: 亚麻酸乙酯 d5) 目录号 : GC45601
An internal standard for the quantification of α-linolenic acid ethyl ester
Cas No.:203633-16-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
α-Linolenic acid ethyl ester-d5 is intended for use as an internal standard for the quantification of α-linolenic acid ethyl ester by GC- or LC-MS. α-Linolenic acid ethyl ester is an esterified form of α-linolenic acid . It increases cyclin E levels and the activity of Cdk2/cyclin E, ERK, and JNK in hepatic stellate cells when used at a concentration of 50 μM.1 α-Linolenic acid ethyl ester (25 μg/ml) inhibits the growth of S. mutans, C. albicans, and P. gingivalis by 98, 72, and 92%, respectively, in vitro.2 It has been found in biodiesel produced from castor oil using ethanol.3 α-Linolenic acid ethyl ester has been used as a substrate in lipid peroxidation assays for antioxidant activity.4
References
1. Li, J., Hu, W., Baldassare, J.J., et al. The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells. Life Sci. 73(9), 1083-1096 (2003).
2. Huang, C.B., and Ebersole, J.L. A novel bioactivity of omega-3 polyunsaturated fatty acids and their ester derivatives. Mol. Oral Microbiol. 25(1), 75-80 (2010).
3. Concei••o, M.M., Fernandes, V.J., Jr., Bezerra, A.F., et al. Dynamic kinetic calculation of castor oil biodiesel. J. Therm. Anal. Calorim. 87(3), 865-869 (2007).
4. Miyake, T., and Shibamoto, T. Antioxidative activities of natural compounds found in plants. J. Agric. Food Chem. 45(5), 1819-1822 (1997).
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2103 mL | 16.0514 mL | 32.1027 mL |
| 5 mM | 0.6421 mL | 3.2103 mL | 6.4205 mL |
| 10 mM | 0.321 mL | 1.6051 mL | 3.2103 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。