Ginkgetin
(Synonyms: 银杏双黄酮) 目录号 : GC31717
A biflavonoid with diverse biological activities
Cas No.:481-46-9
Sample solution is provided at 25 µL, 10mM.
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Ginkgetin is a biflavonoid that has been isolated from G. biloba and has diverse biological activities, including pro-apoptotic, antiproliferative, anti-inflammatory, anti-atherosclerosis, and neuroprotective properties.1,2,3,4 It inhibits the proliferation of OVCAR-3 ovarian and HeLa cervical cancer cells (EC50s = 3 and 5.2 μg/ml, respectively) and induces apoptosis and caspase-3 cleavage in OVCAR-3 cells when used at a concentration of 3 μg/ml.1 Topical ginkgetin (20 μg/ear) reduces ear edema and prostaglandin E2 levels in a mouse model of chronic skin inflammation induced by phorbol 12-myristate 13-acetate .2 It decreases the thickness of the intima-media and lipid plaque deposition in the thoracic aorta in a rat model of high-fat diet-induced atherosclerosis when administered at a dose of 100 mg/kg.3 Ginkgetin (0.8 mg/kg per day) improves sensorimotor coordination and increases the time spent on a rotating bar in a mouse model of Parkinson's disease induced by MPTP.4
1.Su, Y., Sun, C.M., Chuang, H.H., et al.Studies on the cytotoxic mechanisms of ginkgetin in a human ovarian adenocarcinoma cell lineNaunyn Schmiedebergs Arch. Pharmacol.362(10)82-90(2000) 2.Lim, H., Son, K.H., Chang, H.W., et al.Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammationBiol. Pharm. Bull.29(5)1046-1049(2006) 3.Lian, N., Tong, J., Li, W., et al.Ginkgetin ameliorates experimental atherosclerosis in ratsBiomed. Pharmacother.102510-516(2018) 4.Wang, Y.Q., Wang, M.Y., Fu, X.R., et al.Neuroprotective effects of ginkgetin against neuroinjury in Parkinson's disease model induced by MPTP via chelating ironFree Radic. Res.49(9)1069-1080(2015)
| Cas No. | 481-46-9 | SDF | |
| 别名 | 银杏双黄酮 | ||
| Canonical SMILES | OC1=CC(O)=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=C1C4=CC(C(OC5=CC(OC)=CC(O)=C56)=CC6=O)=CC=C4OC | ||
| 分子式 | C32H22O10 | 分子量 | 566.51 |
| 溶解度 | DMSO : ≥ 83.3 mg/mL (147.04 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7652 mL | 8.826 mL | 17.6519 mL |
| 5 mM | 0.353 mL | 1.7652 mL | 3.5304 mL |
| 10 mM | 0.1765 mL | 0.8826 mL | 1.7652 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet