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Ginkgolide B Sale

(Synonyms: 银杏内酯 B; 白果苦内酯 B; BN-52021) 目录号 : GN10453

A PAFR antagonist

Ginkgolide B Chemical Structure

Cas No.:15291-77-7

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20mg
¥378.00
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Sample solution is provided at 25 µL, 10mM.

Description

Ginkgolide B (BN-52021), an important active terpenoid from Ginkgo biloba leaves, is reported to increase cell viability and decrease cell apoptosis.IC50 value:Target:In vitro: Ginkgolide B (0.2 or 0.4 μg/ml) was added to the culture medium in vitro led to increases in cell viability and decreases in the number of hippocampal cells undergoing AAPH-induced apoptosis [1]. Ginkgolide B caused a dose-related protection against dysrhythmias; the antiarrhythmic effect of ginkgolide B was comparable to that of diltiazem and superior to the activity of metoprolol. Ginkgolide B can presumably prevent the re-entry mechanism involved in the development of ischemia-induced rhythm disturbances [2].In vivo: Oral administration of ginkgolide B (2 mg/kg/day, p.o.) caused a significant increase in cell viability and a highly significant decrease in the numbers of both spontaneously occurring and AAPH-induced apoptoses.

References:
[1]. Jean R. Rapin, et al. In vitro and in vivo effects of an extract of Ginkgo biloba (EGb 761), ginkgolide B, and bilobalide on apoptosis in primary cultures of rat hippocampal neurons. Drug Development Research, 1998, 45 (1):1-43
[2]. Matyas Koltai, et al. Ginkgolide B protects isolated hearts against arrhythmias induced by ischemia but not reperfusion. European Journal of Pharmacology, 1989, 164 (2): 293-302

化学性质

Cas No. 15291-77-7 SDF
别名 银杏内酯 B; 白果苦内酯 B; BN-52021
Canonical SMILES O=C1O[C@@]2([H])C([C@@]([C@]([C@@]3([H])OC4=O)([C@]4([H])C([H])([H])[H])O[H])1O[C@]5([H])OC6=O)(C3([H])O[H])C5([C@@]6([H])O[H])C(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])([H])C2([H])[H]
分子式 C20H24O10 分子量 424.4
溶解度 DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 14 mg/ml 储存条件 Store at 2-8°C Dry, sealed and protect from light
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1 mM 2.3563 mL 11.7813 mL 23.5627 mL
5 mM 0.4713 mL 2.3563 mL 4.7125 mL
10 mM 0.2356 mL 1.1781 mL 2.3563 mL
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