Glipizide-d11
(Synonyms: 格列吡嗪 d11) 目录号 : GC47404
An internal standard for the quantification of glipizide
Cas No.:1189426-07-0
Sample solution is provided at 25 µL, 10mM.
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Glipizide-d11 is intended for use as an internal standard for the quantification of glipizide by GC- or LC-MS. Glipizide is a hypoglycemic agent.1 It inhibits ATP-sensitive potassium (KATP) channels in primary mouse pancreatic β cells (IC50 = 6.4 nM). Glipizide induces insulin release from isolated rat pancreatic tissue with an EC50 value of 40 nM.2 Dietary administration of glipizide (5 mg/kg per day for 10 days) increases the number of insulin receptors on isolated and purified mouse liver plasma membranes.3 It reduces plasma glucose and triglyceride, but not total cholesterol, levels and increases plasma insulin levels in a rat model of diabetes induced by a high-fat diet and streptozotocin when administered orally at a dose of 5 mg/kg.4 Formulations containing glipizide have been used in the treatment of type 2 diabetes.
1.ZÜnkler, B.J., Lenzen, S., MÄnner, K., et al.Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cellsNaunyn-Schmiedebergs Arch. Pharmacol.337(2)225-230(1998) 2.Herchuelz, A., and Malaisse, W.J.Insulinotropic potency of glipizide in vitroDiabetologia309-310(1973) 3.Feinglos, M.N., and Lebovitz, H.E.Sulphonylureas increase the number of insulin receptorsNature276(5684)184-185(1978) 4.Srinivasan, K., Viswanad, B., Asrat, L., et al.Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screeningPharmacol. Res.52(4)313-320(2005)
| Cas No. | 1189426-07-0 | SDF | |
| 别名 | 格列吡嗪 d11 | ||
| Canonical SMILES | CC1=CN=C(C(NCCC2=CC=C(S(NC(NC3([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C3([2H])[2H])=O)(=O)=O)C=C2)=O)C=N1 | ||
| 分子式 | C21H16D11N5O4S | 分子量 | 456.6 |
| 溶解度 | DMSO: slightly soluble,Ethyl Acetate: slightly soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1901 mL | 10.9505 mL | 21.901 mL |
| 5 mM | 0.438 mL | 2.1901 mL | 4.3802 mL |
| 10 mM | 0.219 mL | 1.0951 mL | 2.1901 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet