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Glycine-β-muricholic Acid Sale

(Synonyms: Gly-MCA, GβMCA) 目录号 : GC40911

An intestine-selective FXR antagonist

Glycine-β-muricholic Acid Chemical Structure

Cas No.:66225-78-3

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥3,457.00
现货
5mg
¥3,375.00
现货
10mg
¥5,400.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Glycine-β-muricholic acid (GβMCA) is an intestine-selective antagonist of the farnesoid X receptor (FXR) and the glycine-conjugated form of the murine-specific primary bile acid β-muricholic acid .[1] [2]  It inhibits expression of the FXR target genes Shp and Fgf15 induced by the FXR ligands chenodeoxycholic acid and GW 4064 in Caco-2 cells when used at a concentration of 100 μM. GβMCA is resistant to hydrolysis by fecal bile salt hydrolase (BSH) isolated from gut microbiota, indicating gut stability. Dietary administration of GβMCA (10 mg/kg) decreases Shp and Fgf15 mRNA expression in ileum, but not liver, and reduces ceramide levels and expression of the ceramide synthesis-related genes Sptlc2, Sptlc3, Cers2, Cers4, Degs1, Degs2, Smpd3, and Smpd4 in ileum of mice with high-fat diet-induced obesity and db/db mice. It also prevents weight gain, reduces blood glucose levels, and increases insulin sensitivity as well as prevents development of cholestasis and necrotic lesions in liver of mice with high-fat diet-induced obesity.

Reference:
[1]. Jiang, C., Xie, C., Lv, Y., et al. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat. Commun. 6, 10166 (2015).
[2]. Wahlström, A., Sayin, S.I., Marschall, H.-I., et al. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24(1), 41-50 (2016).

Chemical Properties

Cas No. 66225-78-3 SDF
别名 Gly-MCA, GβMCA
化学名 N-[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]-glycine
Canonical SMILES O[C@@H]1CC[C@@]2(C)[C@@]([C@H](O)[C@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCC(O)=O)=O)([H])C1
分子式 C26H43NO6 分子量 465.6
溶解度 20mg/mL in ethanol, or in DMSO, 20mg/mL in DMF 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 2.1478 mL 10.7388 mL 21.4777 mL
5 mM 0.4296 mL 2.1478 mL 4.2955 mL
10 mM 0.2148 mL 1.0739 mL 2.1478 mL
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