Glycogen
(Synonyms: 糖原) 目录号 : GC33804
糖原是一种糖酵解中间体和高能磷酸盐，可作为人类、动物、真菌和细菌的一种能量储存形式。
Cas No.:9005-79-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Glycogen is a glycolytic intermediates and high-energy phosphates that can serve as a form of energy storage in humans, animals, fungi, and bacteria.
[1]. Harris RC, et al. Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values. Scand J Clin Lab Invest. 1974 Apr;33(2):109-20.
| Cas No. | 9005-79-2 | SDF | |
| 别名 | 糖原 | ||
| Canonical SMILES | [Glycogen] | ||
| 分子式 | C24H42O21 | 分子量 | 666.57 |
| 溶解度 | Water : 50 mg/mL (75.01 mM) | 储存条件 | Store at 2-8°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.5002 mL | 7.5011 mL | 15.0022 mL |
| 5 mM | 0.3 mL | 1.5002 mL | 3.0004 mL |
| 10 mM | 0.15 mL | 0.7501 mL | 1.5002 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Glycogen and its metabolism: some new developments and old themes
Biochem J 2012 Feb 1;441(3):763-87.PMID:22248338DOI:10.1042/BJ20111416.
Glycogen is a branched polymer of glucose that acts as a store of energy in times of nutritional sufficiency for utilization in times of need. Its metabolism has been the subject of extensive investigation and much is known about its regulation by hormones such as insulin, glucagon and adrenaline (epinephrine). There has been debate over the relative importance of allosteric compared with covalent control of the key biosynthetic enzyme, Glycogen synthase, as well as the relative importance of glucose entry into cells compared with Glycogen synthase regulation in determining Glycogen accumulation. Significant new developments in eukaryotic Glycogen metabolism over the last decade or so include: (i) three-dimensional structures of the biosynthetic enzymes glycogenin and Glycogen synthase, with associated implications for mechanism and control; (ii) analyses of several genetically engineered mice with altered Glycogen metabolism that shed light on the mechanism of control; (iii) greater appreciation of the spatial aspects of Glycogen metabolism, including more focus on the lysosomal degradation of Glycogen; and (iv) Glycogen phosphorylation and advances in the study of Lafora disease, which is emerging as a Glycogen storage disease.
The dynamic life of the Glycogen granule
J Biol Chem 2018 May 11;293(19):7089-7098.PMID:29483195DOI:10.1074/jbc.R117.802843.
Glycogen, the primary storage form of glucose, is a rapid and accessible form of energy that can be supplied to tissues on demand. Each Glycogen granule, or "glycosome," is considered an independent metabolic unit composed of a highly branched polysaccharide and various proteins involved in its metabolism. In this Minireview, we review the literature to follow the dynamic life of a Glycogen granule in a multicompartmentalized system, i.e. the cell, and how and where Glycogen granules appear and the factors governing its degradation. A better understanding of the importance of cellular compartmentalization as a regulator of Glycogen metabolism is needed to unravel its role in brain energetics.
Glycogen as a Building Block for Advanced Biological Materials
Adv Mater 2020 May;32(18):e1904625.PMID:31617264DOI:10.1002/adma.201904625.
Biological nanoparticles found in living systems possess distinct molecular architectures and diverse functions. Glycogen is a unique biological polysaccharide nanoparticle fabricated by nature through a bottom-up approach. The biocatalytic synthesis of Glycogen has evolved over time to form a nanometer-sized dendrimer-like structure (20-150 nm) with a highly branched surface and a dense core. This makes Glycogen markedly different from other natural linear or branched polysaccharides and particularly attractive as a platform for biomedical applications. Glycogen is inherently biodegradable, nontoxic, and can be functionalized with diverse surface and internal motifs for enhanced biofunctional properties. Recently, there has been growing interest in Glycogen as a natural alternative to synthetic polymers and nanoparticles in a range of applications. Herein, the recent literature on Glycogen in the material-based sciences, including its use as a constituent in biodegradable hydrogels and fibers, drug delivery vectors, tumor targeting and penetrating nanoparticles, immunomodulators, vaccine adjuvants, and contrast agents, is reviewed. The various methods of chemical functionalization and physical assembly of Glycogen nanoparticles into multicomponent nanodevices, which advance Glycogen toward a functional therapeutic nanoparticle from nature and back again, are discussed in detail.
Starch and Glycogen Analyses: Methods and Techniques
Biomolecules 2020 Jul 9;10(7):1020.PMID:32660096DOI:10.3390/biom10071020.
For complex carbohydrates, such as Glycogen and starch, various analytical methods and techniques exist allowing the detailed characterization of these storage carbohydrates. In this article, we give a brief overview of the most frequently used methods, techniques, and results. Furthermore, we give insights in the isolation, purification, and fragmentation of both starch and Glycogen. An overview of the different structural levels of the glucans is given and the corresponding analytical techniques are discussed. Moreover, future perspectives of the analytical needs and the challenges of the currently developing scientific questions are included.
Brain Glycogen Structure and Its Associated Proteins: Past, Present and Future
Adv Neurobiol 2019;23:17-81.PMID:31667805DOI:10.1007/978-3-030-27480-1_2.
This chapter reviews the history of glycogen-related research and discusses in detail the structure, regulation, chemical properties and subcellular distribution of Glycogen and its associated proteins, with particular focus on these aspects in brain tissue.