Glycyl-L-Glutamine (hydrate)
(Synonyms: 甘氨酰-L-谷氨酰胺) 目录号 : GC49509
A dipeptide fragment of β-endorphin
Cas No.:172669-64-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >97.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Glycyl-L-glutamine is a C-terminal dipeptide fragment of β-endorphin .1 It decreases reperfusion damage and increases the time to ischemic contracture in isolated rat hearts in a model of cardiac ischemia-reperfusion injury using eight- and 36-week old rats when used at a concentration of 5 mM.2 Glycyl-L-glutamine (1-100 nmol) inhibits morphine-induced respiratory depression with no effect on morphine-induced analgesia in rats.3 It also inhibits acquisition of place preference, delays the development of tolerance, and reduces withdrawal intensity in morphine-conditioned rats.4
1.Parish, D.C., Smyth, D.G., Normanton, J.R., et al.Glycyl glutamine, an inhibitory neuropeptide derived from β-endorphinNature306(5940)267-270(1983) 2.Almashhadany, A., Alghamdi, O.A., Van der Touw, T., et al.?-Glycyl-?-glutamine provides the isolated and perfused young and middle-aged rat heart protection against ischaemia-reperfusion injuryAmino Acids47(8)1559-1565(2015) 3.Owen, M.D., Unal, C.B., Callahan, M.F., et al.Glycyl-glutamine inhibits the respiratory depression, but not the antinociception, produced by morphineAm. J. Physiol. Regul. Integr. Comp. Physiol.279(5)R1944-R1948(2000) 4.Cavun, S., GÖktalay, G., and Millington, W.R.Glycyl-glutamine, an endogenous β-endorphin-derived peptide, inhibits morphine-induced conditioned place preference, tolerance, dependence, and withdrawalJ. Pharmacol. Exp. Ther.315(2)949-958(2005)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.5208 mL | 22.604 mL | 45.208 mL |
| 5 mM | 0.9042 mL | 4.5208 mL | 9.0416 mL |
| 10 mM | 0.4521 mL | 2.2604 mL | 4.5208 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。