GM CSF Human, CHO
目录号 : GP20356Granulocyte Macrophage-Colony Stimulating Factor Human Recombinant, CHO
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95% as determined by SDS-PAGE. | Source | Chinese Hamster Ovary cells. |
| Phycical Appearance | Sterile filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | CSF-2; MGI-1GM; GM-CSF; Pluripoietin-alpha; Molgramostin; Sargramostim; MGC131935; MGC138897. | ||
| Amino Acid Sequence | APARSPSPST QPWEHVNAIQ EARRLLNLSR DTAAEMNETV EVISEMFDLQ EPTCLQTRLE LYKQGLRGSL TKLKGPLTMM ASHYKQHCPP TPETSCATQI ITFESFKENL KDFLLVIPFD CWEPVQE | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. | ||
| Biological Activity | ED50 < 0.1 ng/ml, determined by the dose dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line). | ||
| Formulation | The GM CSF Human filtered solution (0.27mg/ml) contains 20mM TRIS HCl buffer pH 7.2. | ||
Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) was first characterized as a growth factor that supports the in-vitro colony formation of granulocytes-macrophages progenitor cells (1, 2). It is a pleiotropic cytokine and a member of a family of endogenous cytokines of the hematopoietic system. GM-CSF is produced as a response to immune or inflammatory stimuli by activated cells of the hematopoietic system such as T cells, B cells, macrophages, mast cells and also fibroblasts and alveolar epithelial cells. It plays an important role in regulating the proliferation, differentiation, survival and activation of hematopoietic cells such as granulocytes and monocytes ,neutrophiles, basophiles and eosonophoiles, erythroid cells, megakaryocytes and T cells (3,4).
ED50 < 0.1 ng/ml, determined by the dose dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
Store at 4°C if entire vial will be used within 2-4 weeks.