GNAQ Human
目录号 : GP23363Guanine Nucleotide Binding Protein Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Guanine Nucleotide Binding Protein (G Protein); Q Polypeptide;Guanine Nucleotide-Binding Protein Alpha-Q; CMC1; SWS; GAQ; GuanineNucleotide-Binding Protein G(Q) Subunit Alpha; G-ALPHA-Q; Guaninenucleotide-binding protein G(q) subunit alpha. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMTLESIM ACCLSEEAKE ARRINDEIER QLRRDKRDAR RELKLLLLGTGESGKSTFIK QMRIIHGSGY SDEDKRGFTK LVYQNIFTAM QAMIRAMDTL KIPYKYEHNK AHAQLVREVDVEKVSAFENP YVDAIKSLWN DPGIQECYDR RREYQLSDSTKYYLNDLDRV ADPAYLPTQQ DVLRVRVPTT GIIEYPFDLQ SVIFRMVDVGGQRSERRKWI HCFENVTSIM FLVALSEYDQ VLVESDNENR MEESKALFRT IITYPWFQNS SVILFLNKKDLLEEKIMYSH LVDYFPEYDG PQRDAQAARE FILKMFVDLN PDSDKIIYSH FTCATDTENIRFVFAAVKDT ILQLNLKEYN LV. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | GNAQ protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M UREA and 10% glycerol. | ||
GNAQ, also known as Guanine nucleotide-binding protein belong to the G-alphafamily. Guanine nucleotide-binding proteins (G proteins) are involved asmodulators or transducers in a variety of transmembrane signaling systems. GNAQregulates B-cell selection and survival and is essential in order to preventB-cell-dependent autoimmunity. GNAQ also regulates chemotaxis of BM-derived neutrophilsand dendritic cells, in vitro. GNAQ is an alpha subunit in the Gq class,couples a seven-transmembrane domain receptor to activation ofphospolipase C-beta. Mutations at this locus have been connectedwith problems in platelet activation and aggregation. A related pseudogene toGNAQ exists on chromosome 2.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.