GnRH II (trifluoroacetate salt)
(Synonyms: Gonadotropin-releasing Hormone II, LHRH II) 目录号 : GC43782A GnRHR agonist
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Gonadotropin-releasing hormone II (GnRH II) is a peptide agonist of the GnRH receptor (GnRHR). It binds to human recombinant type I and marmoset type II GnRHRs (IC50s = 26.1 and 1.07 nM, respectively, in COS-7 cells) and stimulates inositol phosphate production (EC50s = 7.41 and 0.45 nM, respectively). GnRH II stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from cultured primary rhesus monkey anterior pituitary cells (EC50s = 0.37 and 0.59 nM, respectively) and dose-dependently stimulates LH and FSH release from cultured primary rat anterior pituitary cells. In vivo, GnRH II (1 μg/kg, i.v.) increases plasma LH levels in White Leghorn pullets but does not affect plasma FSH levels. It also decreases food intake in zebrafish and increases courtship behavior in female white-crowned sparrows when administered intracerebroventricularly at doses of 1 pmol/g and 100 ng, respectively.
Cas No. | SDF | ||
别名 | Gonadotropin-releasing Hormone II, LHRH II | ||
Canonical SMILES | NC(CNC([C@@H]1CCCN1C([C@H](CC2=CC=C(C=C2)O)NC([C@H](CC3=CNC4=C3C=CC=C4)NC(CNC([C@H](CC5=CN=CN5)NC([C@@H](NC([C@H](CC6=CNC7=C6C=CC=C7)NC([C@H](CC8=CN=CN8)N(C([C@@H]9CCC(N9)=O)=O)[H])=O)=O)CO)=O)=O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F | ||
分子式 | C60H69N17O13•XCF3COOH | 分子量 | 1236.3 |
溶解度 | Water: 1 mg/ml | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 0.8089 mL | 4.0443 mL | 8.0887 mL |
5 mM | 0.1618 mL | 0.8089 mL | 1.6177 mL |
10 mM | 0.0809 mL | 0.4044 mL | 0.8089 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。