Gossypetin

Gossypetin is a flavonoid that has been found in H. sabdariffa and has diverse biological activities.^1,2,3 It inhibits the MAP2K kinases MKK3 and MKK6 in a concentration-dependent manner, as well as induces apoptosis and cell cycle arrest at the G₂ phase in KYSE-450 and KYSE-510 esophageal cancer cells when used at a concentration of 20 ?M.¹ Gossypetin scavenges DPPH radicals and inhibits copper-induced lipid peroxidation in cell-free assays.² It reduces high-fat diet-induced increases in serum cholesterol, triglycerides, and LDL-cholesterol levels, as well as decreases aortic extracellular lipid and foam cell deposits in a rabbit model of atherosclerosis when administered at a dose of 10 mg/kg.³

1.Xie, X., Liu, K., Liu, F., et al.Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivoCancer Lett.442126-136(2019) 2.Chen, J.-H., Tsai, C.-W., Wang, C.-P., et al.Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formationToxicol. Appl. Pharmacol.272(2)313-324(2013) 3.Lin, H.-H.In vitro and in vivo atheroprotective effects of gossypetin against endothelial cell injury by induction of autophagyChem. Res. Toxicol.28(2)202-215(2015)