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GSK-2793660 Sale

目录号 : GC62634

GSK-2793660(游离碱)是一种口服的、不可逆的组织蛋白酶 C (CTSC) 抑制剂。

GSK-2793660 Chemical Structure

Cas No.:1613458-70-0

规格 价格 库存 购买数量
5 mg
¥5,580.00
现货
10 mg
¥8,820.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

GSK-2793660 is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 can be used for the research of bronchiectasis[1][2].

GSK-2793660 is a cathepsin C (also known as dipeptidyl peptidase I enzyme) inhibitor for the reaearch of cystic fibrosis, non-cystic fibrosis bronchiectasis, anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis and bronchiectasis[1].

[1]. Szcze?niak P, et al. The Synthesis of α,α-Disubstituted α-Amino Acids via Ichikawa Rearrangement. J Org Chem. 2016 Feb 5;81(3):1057-74.
[2]. Miller BE, et al. Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660). Br J Clin Pharmacol. 2017 Dec;83(12):2813-2820.

Chemical Properties

Cas No. 1613458-70-0 SDF
分子式 C20H27N3O3 分子量 357.45
溶解度 DMSO : 100 mg/mL (253.87 mM; Need ultrasonic) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.7976 mL 13.988 mL 27.9759 mL
5 mM 0.5595 mL 2.7976 mL 5.5952 mL
10 mM 0.2798 mL 1.3988 mL 2.7976 mL
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Research Update

The Synthesis of α,α-Disubstituted α-Amino Acids via Ichikawa Rearrangement

J Org Chem 2016 Feb 5;81(3):1057-74.PMID:26726732DOI:10.1021/acs.joc.5b02628.

An approach to α,α-disubstituted α-amino acids is reported. The key step is allyl cyanate-to-isocyanate rearrangement. As demonstrated, the resultant allyl isocyanates can be directly trapped with various nucleophiles, for instance, alcohols, amines, and organometallic reagents, to provide a broad range of N-functionalized allylamines. The developed method has been successfully applied in the synthesis of two bioactive peptides: 2-aminoadamantane-2-carboxylic acid derived P2X7-evoked glutamate release inhibitor and 4-amino-tetrahydropyranyl-4-carboxylic acid derived dipeptide GSK-2793660, which is currently in clinical trials as cathepsin C inhibitor for the treatment of cystic fibrosis, noncystic fibrosis bronchiectasis, ANCA-associated vasculitis and bronchiectasis.