Guanidinoethyl sulfonate
(Synonyms: 脒基牛磺酸,NSC 667063,Taurocyamine) 目录号 : GC15461
A natural taurine metabolite
Cas No.:543-18-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Guanidinoethyl sulfonate is a competitive glycine receptor antagonist.
The glycine receptor, the receptor for the amino acid neurotransmitter glycine, is an ionotropic receptor producing its effects via chloride current. Glycine receptor is one of the most widely distributed inhibitory receptors in the central nervous system and has important roles in various physiological processes.
In vitro: Guanidinoethyl sulphonate was found to be an analogue of taurine and an inhibitor of taurine transport. Guanidinoethyl sulphonate was also shown to be a weak agonist at GABA(A) receptors, and was able to antagonize GABA-evoked responses. Guanidinoethyl sulphonate did not gate GlyR. 3. but antagonized glycine responses in a concentration-dependent and surmountable manner. Glycine receptor-mediated taurine responses were competitively antagonized by guanidinoethyl sulphonate. Taurine dose-response curves, in contrast to the glycine dose-response curves were shifted by guanidinoethyl sulphonate to the right in a parallel manner [1].
In vivo: Guanidinoethyl sulphonate delivered in the drinking water of rats for 1 month could effectively reduce taurine levels in brain structures and outside the brain by between 50 and 80 %, depending on the tissue. This partial taurine depletion could not affect either basal synaptic transmission or the late phase of long-term potentiation in hippocampal slices. In-vivo microdialysis studies in the hippocampus demonstrated that guanidinoethyl sulphonate was able to reduce extracellular taurine levels and the magnitude of taurine released in response to the application of either N-methyl-D-aspartate or a hypoosmotic solution [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Sergeeva, O. A.,Chepkova, A.N., and Hass, H.L. Guanidinoethyl sulphonate is a glycine receptor antagonist in striatum. British Journal of Pharmacology 137, 855-860 (2002).
[2] Suárez LM, Muoz MD, González JC, Bustamante J, Del Río RM, Solís JM. The taurine transporter substrate guanidinoethyl sulfonate mimics the action of taurine on long-term synaptic potentiation. Amino Acids. 2016 Nov;48(11):2647-2656. Epub 2016 Jul 15.
| Cas No. | 543-18-0 | SDF | |
| 别名 | 脒基牛磺酸,NSC 667063,Taurocyamine | ||
| 化学名 | 2-[(aminoiminomethyl)amino]-ethanesulfonic acid | ||
| Canonical SMILES | OS(CCNC(N)=N)(=O)=O | ||
| 分子式 | C3H9N3O3S | 分子量 | 167.2 |
| 溶解度 | ≤1mg/ml in PBS | 储存条件 | Store at -20°C,protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 5.9809 mL | 29.9043 mL | 59.8086 mL |
| 5 mM | 1.1962 mL | 5.9809 mL | 11.9617 mL |
| 10 mM | 0.5981 mL | 2.9904 mL | 5.9809 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。