Guanoclor
(Synonyms: 胍氯酚,Vatensol) 目录号 : GC45678A guanidinium antihypertensive
Cas No.:5001-32-1
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >95.00%
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Guanoclor is an antihypertensive agent that binds to non-adrenergic sites in pig kidney membranes (IC50 = 10 nM).1,2 It inhibits the Na+/H+ exchanger in pig kidney membranes (IC50 = 1 μM) and cell-free bovine dopamine β-hydroxylase (IC50 = 90 μM). Guanoclor inhibits electrically stimulated norepinephrine release from spleen.1 It decreases norepinephrine levels in dog heart, spleen, hypothalamus, and adrenal gland when administered at a dose of 10 mg/kg per day for six weeks. It decreases adrenal catecholamine levels in rats when administered at a dose of 20 mg/kg per day for six weeks. Guanoclor (20 mg/kg) decreases experimentally induced hypertension and the tyramine-induced pressor response and increases the norepinephrine-induced pressor response in non-anesthetized dogs.
|1. Lawrie, T.D., Lorimer, A.R., McAlpine, S.G., et al. Clinical trial and pharmacological study of compound 1029. ("Vatensol"). Br. Med. J. 1(5380), 402-406 (1964).|2. Vigne, P., Lazdunski, M., and Frelin, C. Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes. Eur. J. Pharmacol. 160(2), 295-298 (1989).
Cas No. | 5001-32-1 | SDF | |
别名 | 胍氯酚,Vatensol | ||
Canonical SMILES | ClC1=C(OCCNNC(N)=N)C(Cl)=CC=C1 | ||
分子式 | C9H12Cl2N4O | 分子量 | 263.1 |
溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
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1 mg | 5 mg | 10 mg | |
1 mM | 3.8008 mL | 19.0042 mL | 38.0084 mL |
5 mM | 0.7602 mL | 3.8008 mL | 7.6017 mL |
10 mM | 0.3801 mL | 1.9004 mL | 3.8008 mL |
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1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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Spectrophotometric analysis of some guanidino drugs by acid-dye and charge-transfer complexation methods
J Pharm Biomed Anal 1993 Aug;11(8):639-45.PMID:8257728DOI:10.1016/0731-7085(93)80169-2.
Two spectrophotometric methods are described for the determination of guanethidine sulphate (I), guanfacine hydrochloride (II), Guanoclor sulphate (III), guanoxan sulphate (IV) and debrisoquine sulphate (V). The first method involves ion-pair formation of the selected compounds (I-V) with bromocresol purple at pH 3.8. The yellow ion pair is extracted with chloroform and the absorbance is measured at about 415 nm. The second method is based on the reaction of the basic guanidino compounds (I, III-V) with iodine in chloroform to give molecular charge-transfer complexes with maximum absorbance at 292 and 345 nm. Beer's law was obeyed for both methods and the relative standard deviations were found to be less than 2%. The apparent molar absorptivities were found to be 2.1 x 10(4) to 6.9 x 10(4) l mol-1 cm-1 using bromocresol purple and 0.7 x 10(4) to 2.4 x 10(4) l mol-1 cm-1 using iodine. The investigated drugs were assayed in tablets. The mean percentage recoveries were found to be 99.8-100.8% by the acid-dye method and around 100.4% by the charge-transfer complexation method.
Conformational populations for antihistamines and antihypertensives in solution
J Pharm Sci 1976 Apr;65(4):612-4.PMID:5591DOI:10.1002/jps.2600650437.
The conformations in aqueous solution were determined for the XCH2CH2N systems of some antihistamines (H1-receptor antagonists) and some adrenergic neuron blocking agents, including the antihypertensive drugs guanethidine and Guanoclor. The rotameric species thought to be the pharmacologically active one is often not the only rotamer present in solution.