Gypsogenin

Gypsogenin (639-14-5) is a naturally occurring biochemical that shows anti-ABL1 kinase and anti-chronic Myelogenous Leukemia activities.

Gypsogenin (1) was obtained by acidic hydrolysis from its saponin.While the parent compound 1 acted as a selective inhibitor for butyrylcholinesterase (from equus) possessing a moderate mixed-type inhibition of the enzyme, Ki values as low as 2.67 0.59 μM were determined for (3β,4α) 3-O-acetyl-olean-12-ene-23,28-dinitrile (11) and acetylcholinesterase (AChE, from electric eel).?Thus, 11 possesses one-fifth of the inhibitory activity of the 'gold standard' galantamine hydrobromide;?this compound is one of the first pentacyclic triterpenoids described as a potent AChE-selective inhibitor

Gypsogenin (639-14-5) 是一种天然存在的生化物质，具有明显的抗血管生成活性和对 H460 的细胞毒性，拥有抗 ABL1 激酶和抗慢性骨髓性白血病作用。
Gypsogenin（1）通过其皂苷的酸性水解获得。而原始化合物1作为特定的丁酰 Choline 酯酶（来自马）的选择性抑制剂，表现出该酶的中度混合型抑制，其Ki值低至2.67 ± 0.59 μM，是针对（3β,4α）3-O-乙酰基-齐墩果烷-12烯-23,28-二腈（11）及乙酰 Choline 酯酶（AChE，来源于电鳗）的。因此，11的抑制活性为“黄金标准”盐酸伽兰他敏的五分之一；此化合物是首批被描述为强效AChE选择性抑制剂的五环三萜之一。