H-D-Glu-OH
(Synonyms: D-谷氨酸; (R)-Glutamic acid) 目录号 : GA10629
D-谷氨酸是L-谷氨酸的对映异构体，广泛用于药物和食品中。
Cas No.:6893-26-1
Sample solution is provided at 25 µL, 10mM.
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D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.
Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers[1]. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens[2].
D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals[1]. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid[3].
References:
[1]. Han H, et al. Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52.
[2]. Chung SY, et al. IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids. Food Chem. 2015 Jan 1;166:248-53.
[3]. Wilson W, et al. The metabolism of D- and L- glutamic acid in the rat. J Biol Chem. 1961 Feb;236:365-9.
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Animal experiment: |
Rats: Male albino rats are given injections of L- or D-glutamic acid-2-C14, DL-glutamic acid-5-C14, or D-glutamic acid-5-C14. Injections by stomach tube or into the cecum are performed while the animals are under ether anesthesia. After the rats are killed, the “carcass” and liver glutamic acids are isolated, degraded, and assayed for radioactivity. “Carcass” refers to the entire animal, except liver, including the ished gastrointestinal tract[3]. |
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References: [1]. Han H, et al. Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52. |
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| Cas No. | 6893-26-1 | SDF | |
| 别名 | D-谷氨酸; (R)-Glutamic acid | ||
| 化学名 | (2R)-2-aminopentanedioic acid | ||
| Canonical SMILES | C(CC(=O)O)C(C(=O)O)N | ||
| 分子式 | C5H9NO4 | 分子量 | 147.1 |
| 溶解度 | PBS (pH 7.2): 1 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.7981 mL | 33.9905 mL | 67.981 mL |
| 5 mM | 1.3596 mL | 6.7981 mL | 13.5962 mL |
| 10 mM | 0.6798 mL | 3.399 mL | 6.7981 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet