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H-Ile-Pro-Pro-OH Sale

目录号 : GC32611

A peptide ACE inhibitor

H-Ile-Pro-Pro-OH Chemical Structure

Cas No.:26001-32-1

规格 价格 库存 购买数量
10mg
¥714.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

H-Ile-Pro-Pro-OH (IPP) is a peptide inhibitor of angiotensin converting enzyme (ACE; IC50 = 5 ?M).1 It inhibits acetylcholine-induced nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 1 ?M and induces vasorelaxation in precontracted isolated rat aortic rings.2 IPP (0.3 mg/kg) decreases systolic blood pressure in spontaneously hypertensive, but not normotensive, rats.3 Dietary administration of IPP reduces plasma levels of total cholesterol, HDL-cholesterol, and triglycerides, mRNA expression of IL-6 and IL-1β, and aortic arch intimal thickening and atherosclerotic plaque formation in ApoE-/- mice.4

1.Nakamura, Y., Yamamoto, N., Sakai, K., et al.Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milkJ. Dairy Sci.78(4)777-783(1995) 2.Hirota, T., Nonaka, A., Matsushita, A., et al.Milk casein-derived tripeptides, VPP and IPP induced NO production in cultured endothelial cells and endothelium-dependent relaxation of isolated aortic ringsHeart Vessels26(5)549-556(2011) 3.Nakamura, Y., Yamamoto, N., Sakai, K., et al.Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzymeJ. Dairy Sci.78(6)1253-1257(1995) 4.Nakamura, T., Hirota, T., Mizushima, K., et al.Milk-derived peptides, Val-Pro-Pro and Ile-Pro-Pro, attenuate atherosclerosis development in apolipoprotein e-deficient mice: A preliminary studyJ. Med. Food16(5)396-403(2013)

Chemical Properties

Cas No. 26001-32-1 SDF
分子式 C16H27N3O4 分子量 325.4
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.0731 mL 15.3657 mL 30.7314 mL
5 mM 0.6146 mL 3.0731 mL 6.1463 mL
10 mM 0.3073 mL 1.5366 mL 3.0731 mL
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