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Halazone Sale

(Synonyms: 哈拉宗) 目录号 : GC39792

Halazone (Pantocide, p-sulfondichloramidobenzoic acid) is widely used to disinfect drinking water.

Halazone Chemical Structure

Cas No.:80-13-7

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50mg
¥405.00
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100mg
¥540.00
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250mg
¥900.00
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500mg
¥1,800.00
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产品描述

Halazone (Pantocide, p-sulfondichloramidobenzoic acid) is widely used to disinfect drinking water.

Chemical Properties

Cas No. 80-13-7 SDF
别名 哈拉宗
Canonical SMILES O=C(O)C1=CC=C(S(=O)(N(Cl)Cl)=O)C=C1
分子式 C7H5Cl2NO4S 分子量 270.09
溶解度 DMSO : 100 mg/mL (370.25 mM; Need ultrasonic) 储存条件 Store at -20°C,unstable in solution, ready to use.
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.7025 mL 18.5123 mL 37.0247 mL
5 mM 0.7405 mL 3.7025 mL 7.4049 mL
10 mM 0.3702 mL 1.8512 mL 3.7025 mL
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Research Update

Redox potential measurements for determining the disinfecting power of chlorinated water

J Hyg (Lond) 1972 Jun;70(2):313-23.PMID:4555890DOI:10.1017/s0022172400022361.

The kill of Escherichia coli within 3 min. was studied in chlorine-demand-free water using sodium hypochlorite, monochloramine, dichloramine, Halazone, chloramine T, cyanuric acid + sodium hypochlorite and cyanuric acid + monochloramine. The redox potential and the available chlorine were measured. The redox potential was found to be better correlated with the disinfecting property of the water than was the amount of available chlorine. For individual pure chlorine compounds, the measuring of available chlorine showed in general a somewhat better correlation with reduction of the bacteria than the redox potential showed.

Effects of some chemical reagents on sodium current inactivation in myelinated nerve fibers of the frog

Biophys J 1986 Oct;50(4):557-64.PMID:2430631DOI:10.1016/S0006-3495(86)83495-6.

The effect of several chemical reagents on the sodium current was studied in voltage-clamped single nerve fibers of the frog. The oxidants Halazone and hypochlorous acid drastically inhibited inactivation. Their effect was similar to that of chloramine T (Wang, 1984a). The curve relating the steady-state inactivation parameter h infinity to the conditioning potential E became nonmonotonic after treatment with the oxidants, i.e., dh infinity/dE greater than 0 for E greater than -20 mV. By contrast, the oxidants periodate, iodate, and hydrogen peroxide (applied for the same time, but at higher concentrations) merely produced a parallel shift of the h infinity(E) curve to more negative values of membrane potential. Diethylpyrocarbonate, a reagent that preferentially modifies histidine groups, had one marked effect: a strong shift of the h infinity(E) curve to more negative values of membrane potential. Almost no effect was observed after application of the tyrosine-reactive reagent N-acetylimidazole. Similarly, the arginine-reactive reagent glyoxal had only minor effects on the Na permeability. The results suggest that methionine is not critically involved in the kinetics of Na current inactivation. Similarly, an essential tyrosine or arginine residue seems to be unavailable to chemical reagents from outside on the frog node of Ranvier. Deduced from the reactivities of (some of) the reagents used, modification of membrane lipids is a tentative explanation for the effects observed on inactivation kinetics.

Inhibition profiling of human carbonic anhydrase II by high-throughput screening of structurally diverse, biologically active compounds

J Biomol Screen 2006 Oct;11(7):782-91.PMID:16858005DOI:10.1177/1087057106289403.

Human carbonic anhydrase II (CA II), a zinc metalloenzyme, was screened against 960 structurally diverse, biologically active small molecules. The assay monitored CA II esterase activity against the substrate 4-nitrophenyl acetate in a format allowing high-throughput screening. The assay proved to be robust and reproducible with a hit rate of approximately 2%. Potential hits were further characterized by determining their IC(50) and K(d) values and tested for nonspecific, promiscuous inhibition. Three known sulfonamide CA inhibitors were identified: acetazolamide, methazolamide, and celecoxib. Other hits were also found, including diuretics and antibiotics not previously identified as CA inhibitors, for example, furosemide and Halazone. These results confirm that many sulfonamide drugs have CA inhibitory properties but also that not all sulfonamides are CA inhibitors. Thus many, but not all, sulfonamide drugs appear to interact with CA II and may target other CA isozymes. The screen also yielded several novel classes of nonsulfonamide inhibitors, including merbromin, thioxolone, and tannic acid. Although these compounds may function by some nonspecific mechanism (merbromin and tannic acid), at least 1 (thioxolone) appears to represent a genuine CA inhibitor. Thus, this study yielded a number of potentially new classes of CA inhibitors and preliminary experiments to characterize their mechanism of action.

Effects of chloramine-T on charge movement and fraction of open channels in frog nodes of Ranvier

Pflugers Arch 1987 Jul;409(3):251-7.PMID:3498145DOI:10.1007/BF00583473.

The effects of chloramine-T, a substance which partially and irreversibly inhibits inactivation of the Na current (Wang 1984), on the on and off charge movement (Qon and Qoff) and on the relative position of the Qon-E and F-E curves were studied on voltage clamped frog nodes of Ranvier. The decrease of Qoff with increasing pulse duration which is seen in normal fibres was much less pronounced in chloramine-T-treated fibres, i.e. chloramine-T inhibited charge immobilization. Also, the decrease of the time constant tau off which normally accompanies the decrease of Qoff was absent in chloramine-T-treated fibres. A correlation (r2 = 0.80) between the relative tau off and the relative Qoff was observed in chloramine-T-treated fibres. The voltage dependence of the on charge movement, Qon-E, was compared with the voltage dependence of the fraction of open channels, F-E. In normal fibres, the F-E curve rose very steeply and crossed the normalized Qon-E curve so that F greater than Qon/Qon max for E greater than -40 mV. After chloramine-T treatment, the F-E curve rose less steeply and remained below the normalized Qon-E curve at all potentials. The effect of Halazone was similar to that of chloramine-T but weaker. The observations about the Qon-E and F-E curve are compared with the findings on the squid giant axon.