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hemagglutinin (332-340) [Influenza A virus] Sale

(Synonyms: H2N-Thr-Gly-Leu-Arg-Asn-Ile-Pro-Ser-Ile-OH ) 目录号 : GP10138

Partial antigenic glycoprotein

hemagglutinin (332-340) [Influenza A virus] Chemical Structure

规格 价格 库存 购买数量
1mg
¥389.00
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5mg
¥1,176.00
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10mg
¥1,806.00
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25mg
¥2,562.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Influenza hemagglutinin (HA) is a type of hemagglutinin found on the surface of the influenza viruses. It is an antigenic glycoprotein. It is responsible for binding the virus to the cell that is being infected. HA proteins bind to cells with sialic acid on the membranes, such as cells in the upper respiratory tract or erythrocytes. [1]
HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane. [2]
Since hemagglutinin is the major surface protein of the influenza A virus and is essential to the entry process, it is the primary target of neutralizing antibodies.


References:
1. Russell RJ, Kerry PS, Stevens DJ, Steinhauer DA, Martin SR, Gamblin SJ, Skehel JJ (November 2008). "Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion". Proc. Natl. Acad. Sci. U.S.A. 105 (46): 17736–41.
2. White JM, Hoffman LR, Arevalo JH, et al. (1997). "Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin". In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.OxfordUniversity Press. pp. 80–104.

Chemical Properties

Cas No. SDF
别名 H2N-Thr-Gly-Leu-Arg-Asn-Ile-Pro-Ser-Ile-OH
Canonical SMILES NC(C(C)O)C(NCC(NC(CC(C)C)C(NC(CCCNC(N)=N)C(NC(CC(N)=O)C(NC(C(C)CC)C(N1C(C(NC(CO)C(NC(C(C)CC)C(O)=O)=O)=O)CCC1)=O)=O)=O)=O)=O)=O
分子式 C42H75N13O13 分子量 970.12
溶解度 ≥ 97mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.0308 mL 5.154 mL 10.308 mL
5 mM 0.2062 mL 1.0308 mL 2.0616 mL
10 mM 0.1031 mL 0.5154 mL 1.0308 mL
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