Heptanoic Acid
(Synonyms: 庚酸) 目录号 : GC48962
A medium-chain fatty acid
Cas No.:111-14-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Heptanoic acid is a medium-chain saturated fatty acid. It is a volatile component of the rancid odor of defective olive oil.1 It has also been found as a volatile component in pig farm wastewater.2 Heptanoic acid induces neurite outgrowth, a marker of neuronal differentiation, in PC12 cells in a concentration-dependent manner and increases the length of neurites when used at a concentration of 7.5 mM.3 [Matreya, LLC. Catalog No. 1196]
1.Oliver-Pozo, C., Aparicio-Ruiz, R., Romero, I., et al.Analysis of volatile markers for virgin olive oil aroma defects by SPME-GC/FID: Possible sources of incorrect dataJ. Agric. Food Chem.63(48)10477-10483(2015) 2.Yo, S.-P.Analysis of volatile fatty acids in wastewater collected from a pig farm by a solid phase microextraction methodChemosphere38(4)823-834(1999) 3.Kamata, Y., Shiraga, H., Tai, A., et al.Induction of neurite outgrowth in PC12 cells by the medium-chain fatty acid octanoic acidNeuroscience146(3)1073-1081(2007)
| Cas No. | 111-14-8 | SDF | |
| 别名 | 庚酸 | ||
| Canonical SMILES | O=C(CCCCCC)O | ||
| 分子式 | C7H14O2 | 分子量 | 130.2 |
| 溶解度 | DMSO : ≥ 100 mg/mL (768.17 mM) | 储存条件 | Room•emperature |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 7.6805 mL | 38.4025 mL | 76.8049 mL |
| 5 mM | 1.5361 mL | 7.6805 mL | 15.361 mL |
| 10 mM | 0.768 mL | 3.8402 mL | 7.6805 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
GC-MS Analysis of Short-Chain Fatty Acids in Feces, Cecum Content, and Blood Samples
Methods Mol Biol 2018;1730:247-256.PMID:29363078DOI:10.1007/978-1-4939-7592-1_17.
Short-chain fatty acids, the end products of fermentation of dietary fibers by the gut microbiota, have been shown to exert multiple effects on mammalian metabolism. For the analysis of short-chain fatty acids, gas chromatography-mass spectrometry is a very powerful and reliable method. Here, we describe a fast, reliable, and reproducible method for the separation and quantification of short-chain fatty acids in mouse feces, cecum content, and blood samples (i.e., plasma or serum) using gas chromatography-mass spectrometry. The short-chain fatty acids analyzed include acetic acid, propionic acid, butyric acid, valeric acid, hexanoic acid, and Heptanoic Acid.
Enhancement of fibrinolysis by EF6265 [(S)-7-amino-2-[[[(R)-2-methyl-1-(3-phenylpropanoylamino)propyl]hydroxyphosphinoyl] methyl]Heptanoic Acid], a specific inhibitor of plasma carboxypeptidase B
J Pharmacol Exp Ther 2004 May;309(2):607-15.PMID:14762098DOI:10.1124/jpet.103.062729.
Plasma procarboxypeptidase B, also known as thrombin-activatable fibrinolysis inhibitor (TAFI), is converted by thrombin into the active enzyme, carboxypeptidase B (CPB)/activated TAFI. Plasma CPB down-regulates fibrinolysis by removing carboxy-terminal lysines, the ligands for plasminogen and tissue-type plasminogen activator (tPA), from partially degraded fibrin. To target thrombosis in a new way, we have identified and optimized a phosphinic acid-containing inhibitor of CPB, EF6265 [(S)-7-amino-2-[[[(R)-2-methyl-1-(3-phenylpropanoylamino) propyl]hydroxyphosphinoyl]methyl]Heptanoic Acid] and determined both the pharmacological profile and pathophysiological role of CPB in rat thrombolysis. EF6265 specifically inhibited plasma CPB activity with an IC(50) (50% inhibitory concentration) of 8.3 nM and enhanced tPA-mediated clot lysis in a concentration-dependent manner. EF6265 decreased detectable thrombi (percentage of glomerular fibrin deposition; control, 98 +/- 1.1; EF6265, 0.1 mg/kg, 27 +/- 9.1) that had been generated by tissue factor in a rat microthrombosis model with concomitant increases in plasma D-dimer concentration (control, <0.5 microg/ml; EF6265, 0.1 mg/kg, 15 +/- 3.5 microg/ml). EF6265 reduced plasma alpha2-antiplasmin activity to a lesser extent than tPA. In an arteriovenous shunt model, EF6265 (1 mg/kg) enhanced exogenous tPA-mediated thrombolysis under the same conditions that neither EF6265 nor tPA (600 kIU/kg) alone reduced thrombi. EF6265 (1 and 30 mg/kg) did not affect the bleeding time in rats. Moreover, it did not prolong the bleeding time evoked by tPA (600 kIU/kg). These results confirm that circulating procarboxypeptidase B functions as a fibrinolysis inhibitor's zymogen and validates the use of CPB inhibitors as both an enhancer of physiological fibrinolysis in microcirculation and as a novel adjunctive agent to tPA for thromboembolic diseases while maintaining a small effect on primary hemostasis.
Regulation of the Docosapentaenoic Acid/Docosahexaenoic Acid Ratio (DPA/DHA Ratio) in Schizochytrium limacinum B4D1
Appl Biochem Biotechnol 2017 May;182(1):67-81.PMID:27832512DOI:10.1007/s12010-016-2311-5.
Docosapentaenoic acid/docosahexaenoic acid ratio (DPA/DHA ratio) in Schizochytrium was relatively stable. But ideally the ratio of DPA/DHA will vary according to the desired end use. This study reports several ways of modulating the DPA/DHA ratio. Incubation times changed the DPA/DHA ratio, and changes in this ratio were associated with the variations in the saturated fatty acid (SFAs) content. Propionic acid sharply increased the SFAs content in lipids, dramatically decreased the even-chain SFAs content, and reduced the DPA/DHA ratio. Pentanoic acid (C5:0) and Heptanoic Acid (C7:0) had similar effects as propionic acid, whereas butyric acid (C4:0), hexanoic acid (C6:0), and octanoic acid (C8:0) did not change the fatty acid profile and the DPA/DHA ratio. Transcription analyses show that β-oxidation might be responsible for this phenomenon. Iodoacetamide upregulated polyunsaturated fatty acid (PUFA) synthase genes, reduced the DHA content, and improved the DPA content, causing the DPA/DHA ratio to increase. These results present new insights into the regulation of the DPA/DHA ratio.
Uptake of a novel anticonvulsant compound, 2-amino-7-phosphono-[4,5-3H]Heptanoic Acid, into mouse brain
Neurosci Lett 1983 May 27;37(1):75-80.PMID:6877661DOI:10.1016/0304-3940(83)90507-4.
The time course of radioactivity in plasma, liver and brain is described following the intraperitoneal injection of 2-amino-7-phosphono-[4,5-3H]Heptanoic Acid in mice. Using high performance liquid chromatography of dansylated extracts of mouse brain the radioactivity attributable to 2-amino-7-phosphono-[4,5-3H]Heptanoic Acid has been determined at 0.25-180 min after injection. The time course, with a peak concentration at 30 min, declining markedly between 90 and 180 min, corresponds to the anticonvulsant action.
Interactions in the Thallium(I) Heptanoate and Heptanoic Acid System: Association, Aggregation, and Phase Behavior
J Colloid Interface Sci 1997 Jan 15;185(2):371-81.PMID:9028891DOI:10.1006/jcis.1996.4610.
The phase, association, and aggregation behavior of the binary system [TlO2C(CH2)5CH3 + HO2C(CH2)5CH3] have been investigated through temperature and enthalpy vs composition diagrams by determination of the thermal behavior of the pure components and 30 mixtures over an interval of nearly 300 K, and by differential scanning calorimetry and polarized microscopy. Total miscibility was observed in liquid and liquid crystalline phases but essentially total immiscibility among crystalline phases. The phase behavior exhibits: (1) Formation of two intermediate compounds which dissociate in the solid state at low temperature; (2) A eutectic reaction at salt molar fraction x = 0.08 about 3 K below the acid melting point; (3) Unimolecular salt:acid association by very strong hydrogen bonding, which undergoes a crystal/crystal transition prior to incongruent melting at 295.5 K, occurring by a highly energetic peritectic reaction in which the compound evolves more than the sum of the total transition enthalpies of both components; (4) Lyotropic mesophase formation at 390.0 K over the x >/= 0.66 composition range by aggregation of a solid and a liquid phase to yield, on heating, a continuous series of liquid crystalline solutions with mixed-lamellar structure and interlamellar spacings around 20 A as determined by powder X-ray diffractometry, their texture being focal conic, consistent with the neat thermotropic mesophase of the pure salt. A tridimensional phase diagram is presented. All these main reactions have been fully characterized by their nature, stoichiometry, and relevant thermodynamic data.