Heptanoyl-Coenzyme A (sodium salt)
(Synonyms: C7-CoA,Enanthyl-coenzyme A,Heptanoyl-CoA) 目录号 : GC91822Heptanoyl-coenzyme A (heptanoyl-CoA) is a derivative of CoA that contains the medium-chain fatty acid heptanoic acid .
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >90.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Heptanoyl-coenzyme A (heptanoyl-CoA) is a derivative of CoA that contains the medium-chain fatty acid heptanoic acid .[1] It inhibits butyryl-CoA:acetate-CoA transferase isolated from the gut bacteria P. elsdenii when used at a concentration of 200 µM. Heptanoyl-CoA levels are increased in primary fibroblasts derived from patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in the presence of heptanoic acid, indicating heptanoyl-CoA formation by short-chain acyl-transferases.[2] It blocks decreases in infarct volume and improvements in motor function induced by the isoquinoline alkaloid berberine in a mouse model of ischemic stroke induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 0.4 mg/kg per day.[3]
References:
[1].Schulman, M., and Valentino, D.Kinetics and catalytic properties of coenzyme A transferase from Peptostreptococcus elsdeniiJ. Bacteriol.128(1)372-378(1976).
[2].Karunanidhi, A., Basu, S., Zhao, X.-J., et al.Heptanoic and medium branched-chain fatty acids as anaplerotic treatment for medium chain acyl-CoA dehydrogenase deficiencyMol. Genet. Metab.140(3)107689(2023).
[3].Duan, H., Hu, J., Deng, Y., et al.Berberine mediates the production of butyrate to ameliorate cerebral ischemia via the gut microbiota in miceNutrients16(1)9(2023).
| Cas No. | N/A | SDF | Download SDF |
| 别名 | C7-CoA,Enanthyl-coenzyme A,Heptanoyl-CoA | ||
| 分子式 | C28H48N7O17P3S•XNa | 分子量 | 879.7 |
| 溶解度 | Water: Soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.1368 mL | 5.6838 mL | 11.3675 mL |
| 5 mM | 0.2274 mL | 1.1368 mL | 2.2735 mL |
| 10 mM | 0.1137 mL | 0.5684 mL | 1.1368 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。