HERV-K
目录号 : GP25522Endogenous retrovirus K Envelope Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Protein is >90% pure as determined by SDS PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Stability | HERV-K although stable at 4°C for 1 week, should be stored below -18°C .Please prevent freeze thaw cycles. | ||
| Formulation | 10mM Phosphate buffer pH 7.2. | ||
HERVK is related with several tumors such as passenger virus, and anti-Retroviral therapy against amyotrophic lateral sclerosis/ALS has exhibited to decrease the symptoms of amyotrophic lateral sclerosis/ALS. High counts of viral sequences exist in the human genome but stay silent. Though, in pathological conditions, these viruses are produced. Human Endogenous Retrovirus-K, is produced in neurons of a subpopulation of patients with amyotrophic lateral sclerosis/ALS, a progressive neurodegenerative disease. The envelope protein of this HERV results in degeneration of neurons, and transgenic animals producing this protein advance an ALS-like syndrome triggered by nucleolar dysfunction in motor neurons. Reactivation of the HERVK is controlled by the transcription factor TDP-43. Therefore, therapeutic tactics against this virus alter the course of the disease.
Detection of Human Endogenious Retrovirus K in individuals is untested.
HERV-K although stable at 4°C for 1 week, should be stored below -18°C .Please prevent freeze thaw cycles.