Hexa-D-Arginine (trifluoroacetate salt)
(Synonyms: Furin Inhibitor II, Hexa-D-Arg-NH2, Hexa-D-Arginine amide, D6R-NH2, (D)RRRRRR-NH2) 目录号 : GC49915
A furin inhibitor
Sample solution is provided at 25 µL, 10mM.
Hexa-D-arginine is an inhibitor of the proprotein convertase furin (Ki = 100 nM).1 It also inhibits West Nile virus nonstructural protein 3 (NS3) protease (Ki = 478 nM). Hexa-D-arginine (1 µg/ml) reduces the proliferation, invasion, and migration of SW 1990 and PaTu 8988 pancreatic cancer cells, as well as decreases the levels of N-cadherin and vimentin and increases E-cadherin levels, markers of the epithelial-to-mesenchymal transition (EMT), in the same cells.2 It improves survival in a rat model of anthrax toxemia induced by the anthrax toxins protective antigen and lethal factor.3
1.Shiryaev, S.A., Ratnikov, B.I., Chekanov, A.V., et al.Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinaseBiochem. J.393(Pt 2)503-511(2006) 2.Zhou, M., Zhang, Y., Wei, H., et al.Furin inhibitor D6R suppresses epithelial?mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo?YAP signaling pathwayOncol. Lett.15(3)3192-3196(2018) 3.Sarac, M.S., Peinado, J.R., Leppla, S.H., et al.Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivoInfect. Immun.72(1)605-605(2004)
Cas No. | SDF | Download SDF | |
别名 | Furin Inhibitor II, Hexa-D-Arg-NH2, Hexa-D-Arginine amide, D6R-NH2, (D)RRRRRR-NH2 | ||
Canonical SMILES | N=C(N)NCCC[C@@H](N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O | ||
分子式 | C36H75N25O6 • XCF3COOH | 分子量 | 954.1 |
溶解度 | Acetonitrile/Water (80:20): 1 mg/ml | 储存条件 | -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
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1 mg | 5 mg | 10 mg |
1 mM | 1.0481 mL | 5.2405 mL | 10.4811 mL |
5 mM | 0.2096 mL | 1.0481 mL | 2.0962 mL |
10 mM | 0.1048 mL | 0.5241 mL | 1.0481 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet