Hexaflumuron
(Synonyms: 六伏隆) 目录号 : GC39683
A chitin synthesis inhibitor
Cas No.:86479-06-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Hexaflumuron is a chitin synthesis inhibitor used to bait and eliminate termite colonies.1 Hexaflumuron spreads efficiently through entire populations through mutual exchange of liquids via regurgitation.2 Termites are unable to metabolize hexaflumuron and clearance is slow, resulting in up to 100% elimination. Hexaflumuron has also been tested for use with the raisin moth, cowpea weevil, and Asiatic rice borer with positive results.3,4
1.Evans, T.A., and Igbal, N.Termite (order Blattodea, infraorder Isoptera) baiting 20 years after commercial releasePest. Manag. Sci.71(7)897-906(2015) 2.Sheets, J.J., Karr, L.L., and Dripps, J.E.Kinetics of uptake, clearance, transfer, and metabolism of hexaflumuron by eastern subterranean termites (Isoptera: Rhinotermitidae)J. Econ. Entomol.93(3)871-877(2000) 3.Khajepour, S., Izadi, H., and Asari, M.J.Evaluation of two formulated chitin synthesis inhibitors, hexaflumuron and lufenuron against the raisin moth, Ephestia figulilellaJ. Insect. Sci.12102(2012) 4.Abo-Elghar, G.E., El-Sheikh, A.E., El-Sayed, F.M., et al.Persistence and residual activity of an organophosphate, pirimiphos-methyl, and three IGRs, hexaflumuron, teflubenzuron and pyriproxyfen, against the cowpea weevil, Callosobruchus maculatus (Coleoptera: Bruchidae)Pest. Manag. Sci.60(1)95-102(2004)
| Cas No. | 86479-06-3 | SDF | |
| 别名 | 六伏隆 | ||
| Canonical SMILES | O=C(NC(NC1=CC(Cl)=C(OC(F)(F)C(F)F)C(Cl)=C1)=O)C2=C(F)C=CC=C2F | ||
| 分子式 | C16H8Cl2F6N2O3 | 分子量 | 461.14 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1685 mL | 10.8427 mL | 21.6854 mL |
| 5 mM | 0.4337 mL | 2.1685 mL | 4.3371 mL |
| 10 mM | 0.2169 mL | 1.0843 mL | 2.1685 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Area-population control of fungus-growing termite, Odontotermes formosanus, using Hexaflumuron durable baits
Pest Manag Sci 2022 Jan;78(1):104-115.PMID:34453384DOI:10.1002/ps.6612.
Background: Fungus-growing termites (Termitidae: Macrotermitinae) are common forest and agriculture pests. To evaluate the efficacy of termite baiting in suppressing field population of fungus-growing termites, a durable termite bait with Hexaflumuron was evenly installed in a one-hectare forest area dominated by a fungus-growing termite, Odontotermes formosanus (Shiraki). Monthly monitoring of termite foraging activity on baits and wood stakes was conducted for 4 years to quantify efficacy of baits. To examine whether the Hexaflumuron led to colony death, pesticides in fungus gardens of active and deceased nests were quantified using a LC-QTOF/MS. Results: After baiting, 50% and 90% of baits were fed upon 10 and 24 months, respectively. After 2 years of baiting, the monthly number of wood stakes occupied by termites was reduced from 34.7 ± 1.8 to 17.6 ± 2.5 (-49.1%), and the number of wood stakes consumed was reduced from 17.7 ± 0.8 to 13.3 ± 1.2 (-25.7%). Hexaflumuron was detected in deceased colonies, including five of six fungus gardens and the fungal tissue of Xyleria grown on fungus gardens, with a concentration of 0.31-20.11 mg kg-1 dry weight. Conclusion: This study demonstrated that durable Hexaflumuron baits consumed by fungus-growing termites were further incorporated into fungus gardens, resulted in colony elimination and negative area-population effects, supporting that durable Hexaflumuron baits are effective in suppressing field populations of fungus-growing termites. © 2021 Society of Chemical Industry.
Acute human lethal poisoning with Hexaflumuron: A case report
Caspian J Intern Med 2021 Winter;12(1):119-123.PMID:33680410DOI:10.22088/cjim.12.1.119.
Background: Hexaflumuron is a benzoyl urea pesticide widely used in agriculture. This is the first case of severe toxicity of Hexaflumuron. Case presentation: A 51-year-old man was admitted to the poisoning ward of the Emam-Reza Hospital for loss of consciousness and hypotension secondary to pesticide toxicity. He had metabolic acidosis, bradycardia, and diffuse erythematous skin color change in the abdomen and legs. The results of toxicology tests were negative except positive test result for tricyclic antidepressants in immunochromatographic assay of urine. He was treated with normal saline, norepinephrine infusion and bicarbonate. His intoxication finally resulted to cardiac arrest and death on the 4th day of hospitalization, secondary to septic shock. Conclusion: Acute poisoning with Hexaflumuron can be life-threatening, thought its LD50 is greater than 5000 mg/kg. It may change the patient's skin color to cherry and cause hypotension, loss of consciousness and metabolic acidosis, however, conclusive evidence to support these assumptions are required.
Dissipation and evaluation of Hexaflumuron residues in chinese cabbage grown in open fields
J Agric Food Chem 2010 Apr 28;58(8):4839-43.PMID:20345168DOI:10.1021/jf904358v.
The dissipation and residue behavior of Hexaflumuron in Chinese cabbage ( Brassica pekinensis ) under different treatments were investigated at two main cabbage-growing areas in China. The dissipation rates of Hexaflumuron in cabbages and soils fit a first-order decay process very well. The dissipation times for 50% of the Hexaflumuron in cabbage and soil were 3.37 and 3.01 days from Hunan province and 5.58 and 3.68 days in Tianjin, respectively, when Chinese cabbage was treated with 180 g of active ingredient (ai)/ha. Hexaflumuron residual times in cabbage and soil were influenced strongly by the application rate and frequency. The application regimen of Hexaflumuron in the cabbage field, a rate of 120 g of ai/ha with two applications at a 7 day interval and a 21 day preharvest interval, was recommended from the point of view of ensuring food safety. The residual levels of Hexaflumuron in cabbages were lower than the standards of the "Positive List System for Agricultural Chemical Residues in Foods" based on the recommended application regimen.
Toxic effects of Hexaflumuron on the development of Coccinella septempunctata
Environ Sci Pollut Res Int 2014 Jan;21(2):1418-24.PMID:23917742DOI:10.1007/s11356-013-2036-8.
Studying the toxic risk of pesticide exposure to ladybird beetles is important from an agronomical and ecological perspective since larval and adult ladybirds are dominant predators of herbivorous pest insects (e.g., aphids) in various crops in China. This article mainly deals with the long-term effects of a single application of the insect growth regulator Hexaflumuron on Coccinella septempunctata. A 72-h and a 33-day toxicity test with Hexaflumuron (single application) were performed, starting with the second instar larvae of C. septempunctata. Exposure doses in the long-term experiment were based on the estimated 72-h acute LR50 (application rate causing 50% mortality) value of 304 g active ingredient (a.i.) ha(-1) for second instar larvae of C. septempunctata. The long-term test used five Hexaflumuron doses as treatment levels (1/50, 1/100, 1/200, 1/400, and 1/800 of the 72-h acute LR50), as well as a solvent control and blank control treatment. The measurement endpoints used to calculate no observed effect application rates (NOERs) included development time, hatching, pupation, adult emergence, survival, and number of eggs produced. Analyzing the experimental data with one-way analysis of variance showed that the single Hexaflumuron application had significant effects on C. septempunctata endpoints in the 33-day test, including effects on development duration (NOER 1.52 g a.i. ha(-1)), hatching (NOER 3.04 g a.i. ha(-1)), pupation (NOER 3.04 g a.i. ha(-1)), and survival (NOER 1.52 g a.i. ha(-1)). These NOERs are lower than the reported maximum field application rate of Hexaflumuron (135 g a.i. ha(-1)) in cotton cultivation, suggesting potential risks to beneficial arthropods.
Study of the photodegradation kinetics and pathways of Hexaflumuron in liquid media
Photochem Photobiol 2014 Nov-Dec;90(6):1219-23.PMID:25039252DOI:10.1111/php.12314.
Hexaflumuron, one of the benzoylphenylurea insect growth regulators, can be leached into surface water and thus having a potential impact on aquatic organisms. In this study, the photodegradation processes of Hexaflumuron under high-pressure mercury lamp irradiation were assessed. The photodegradation kinetics were studied, as were the effects of pH, different light sources, organic solvents and environmental substances, including nitrate ions (NO3(-)), nitrite ions (NO2(-)), ferrous ions (Fe(2+)), ferric ions (Fe(3+)), humic acid, sodium dodecyl sulfate (SDS) and hydrogen peroxide (H2O2). Three photodegradation products in methanol were identified by gas chromatography-mass spectrometry (GC-MS). In general, the degradation of Hexaflumuron followed first-order kinetics. In the four media studied, the photodegradation rate order was n-hexane > methanol > ultrapure water > acetone. Faster degradation was observed under high-pressure mercury lamp irradiation than under xenon lamp irradiation. The pH had a considerable effect, with the most rapid degradation occurring at pH 5.0. The photodegradation rate of Hexaflumuron was promoted in the presence of NO3(-), NO2(-), Fe(2+), humic acid, SDS and H2O2, but inhibited by Fe(3+). Moreover, the presumed photodegradation pathway was proposed to be the cleavage of the urea linkage.