Hexahydrofarnesyl acetone
(Synonyms: 植酮; 6,10,14-Trimethyl-2-pentadecanone) 目录号 : GC61504
A sesquiterpenoid
Cas No.:502-69-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Perhydrofarnesyl acetone is a sesquiterpenoid that has been found in orchid bees (Euglossa).1
1.Zimmermann, Y., Ramírez, S.R., and Eltz, T.Chemical niche differentiation among sympatric species of orchid beesEcology90(11)2994-3008(2009)
| Cas No. | 502-69-2 | SDF | |
| 别名 | 植酮; 6,10,14-Trimethyl-2-pentadecanone | ||
| Canonical SMILES | CC(CCCC(C)CCCC(C)CCCC(C)C)=O | ||
| 分子式 | C18H36O | 分子量 | 268.48 |
| 溶解度 | DMSO: 100 mg/mL (372.47 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.7247 mL | 18.6234 mL | 37.2467 mL |
| 5 mM | 0.7449 mL | 3.7247 mL | 7.4493 mL |
| 10 mM | 0.3725 mL | 1.8623 mL | 3.7247 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Phytotoxic Effects of Plant Essential Oils: A Systematic Review and Structure-Activity Relationship Based on Chemometric Analyses
Plants (Basel) 2020 Dec 25;10(1):36.PMID:33375618DOI:10.3390/plants10010036.
Herbicides are natural or synthetic chemicals used to control unwanted plants (weeds). To avoid the harmful effects of synthetic herbicides, considerable effort has been devoted to finding alternative products derived from natural sources. Essential oils (EOs) from aromatic plants are auspicious source of bioherbicides. This review discusses phytotoxic EOs and their chemical compositions as reported from 1972 to 2020. Using chemometric analysis, we attempt to build a structure-activity relationship between phytotoxicity and EO chemical composition. Data analysis reveals that oxygenated terpenes, and mono- and sesquiterpenes, in particular, play principal roles in the phytotoxicity of EOs. Pinene, 1,8 cineole, linalool, and carvacrol are the most effective monoterpenes, with significant phytotoxicity evident in the EOs of many plants. Caryophyllene and its derivatives, including germacrene, spathulenol, and Hexahydrofarnesyl acetone, are the most effective sesquiterpenes. EOs rich in iridoids (non-terpene compounds) also exhibit allelopathic activity. Further studies are recommended to evaluate the phytotoxic activity of these compounds in pure forms, determine their activity in the field, evaluate their safety, and assess their modes of action.
Hydrodistillation and Microwave Extraction of Volatile Compounds: Comparing Data for Twenty-One Veronica Species from Different Habitats
Plants (Basel) 2022 Mar 28;11(7):902.PMID:35406882DOI:10.3390/plants11070902.
Free volatile compounds were isolated from 21 Croatian Veronica species studied by hydrodistillation (HD) and microwave extraction (ME) and analyzed by gas chromatography coupled with mass spectrometry. Principal Component Analysis (PCA) distinguished some clusters based on the relative proportion of major compounds, such as hexadecanoic acid, Hexahydrofarnesyl acetone, phytol, E-caryophyllene, and caryophyllene oxide, which were identified in all species studied by both isolation methods. In addition to these compounds, germacrene D, δ-selinene, and eicosane were also identified in five samples from dry habitats isolated using ME. Allo-aromadendrene and β-ionone are particularly abundant in five species from wet habitats isolated by both methods. The peculiarities of Veronica species from moderate habitats isolated with HD are benzene acetaldehyde, n-nonanal, and the identification of significant compounds from the hydrocarbon class, while the peculiarity of ME is (E)-β-damascenone. In this article, we present new results on the phytochemical characterization of Veronica species from different habitats. The biological potential of these compounds should be further investigated for a better understanding and utilization of the specialized plant metabolites.
Parrotia persica Yellow and Amber Leaves' Lipophilic Phytochemicals Obtained by Supercritical Carbon Dioxide Extraction
Molecules 2022 Aug 17;27(16):5237.PMID:36014477DOI:10.3390/molecules27165237.
Supercritical carbon dioxide extraction was used for the extraction of Parrotia persica yellow and amber leaves. The lipophilic phytochemicals present in the analyzed leaves were as follows: neophytadiene, Hexahydrofarnesyl acetone, octadecanal, 1-octadecanol, phytol, squalene and α-tocopherol. α-cadinol was present in yellow and β-sitosterol in amber leaves. The Box-Behnken design was used for the optimization of pressure, temperature and CO2 flow rate and response surface methodology for the total extraction yield and α-tocopherol relative amount. The total extraction yield was 1.62% for yellow and 1.52% for amber leaves. The α-tocopherol relative amount was 80.03 mg per 100 g of dry plant material for yellow leaves and 315.30 mg per 100 g of dry plant material for amber leaves. The effects of temperature and CO2 flow rate were found to have a significant influence on the total extraction yield for both plant materials analyzed. The effects of pressure and temperature significantly influenced the α-tocopherol relative amount in both plant materials used. The optimum extraction conditions for the total extraction yield were 30 MPa, 40 °C and 3 kg·h-1 CO2 flow rate for both plant samples. In the case of the α-tocopherol relative amount, the optimum temperature was 40 °C, while the pressure and CO2 flow rate were slightly different. The predicted values matched well with the experimental values for the total extraction yield and α-tocopherol relative amount in all plant materials used for the experiment.
Chemical Composition of Kickxia aegyptiaca Essential Oil and Its Potential Antioxidant and Antimicrobial Activities
Plants (Basel) 2022 Feb 23;11(5):594.PMID:35270064DOI:10.3390/plants11050594.
The exploration of new bioactive compounds from natural resources as alternatives to synthetic chemicals has recently attracted the attention of scientists and researchers. To our knowledge, the essential oil (EO) of Kickxia aegyptiaca has not yet been explored. Thus, the present study was designed to explore the EO chemical profile of K. aegyptiaca for the first time, as well as evaluate its antioxidant and antibacterial activities, particularly the extracts of this plant that have been reported to possess various biological activities. The EO was extracted from the aerial parts via hydrodistillation and then characterized by gas chromatography-mass spectrometry (GC-MS). The extracted EO was tested for its antioxidant activity via the reduction in the free radicals, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). In addition, the EO was tested as an antibacterial mediator against eight Gram-negative and Gram-positive bacterial isolates. Forty-three compounds were identified in the EO of K. aegyptiaca, with a predominance of terpenoids (75.46%). Oxygenated compounds were the main class, with oxygenated sesquiterpenes attaining 40.42% of the EO total mass, while the oxygenated monoterpenes comprised 29.82%. The major compounds were cuminic aldehyde (21.99%), caryophyllene oxide (17.34%), Hexahydrofarnesyl acetone (11.74%), ar-turmerone (8.51%), aromadendrene oxide (3.74%), and humulene epoxide (2.70%). According to the IC50 data, the K. aegyptiaca EO revealed considerable antioxidant activity, with IC50 values of 30.48 mg L-1 and 35.01 mg L-1 for DPPH and ABTS, respectively. In addition, the EO of K. aegyptiaca showed more substantial antibacterial activity against Gram-positive bacterial isolates compared to Gram-negative. Based on the minimum inhibitory concentration (MIC), the EO showed the highest activity against Escherichia coli and Bacillus cereus, with an MIC value of 0.031 mg mL-1. The present study showed, for the first time, that the EO of K. aegyptiaca has more oxygenated compounds with substantial antioxidant and antibacterial activities. This activity could be attributed to the effect of the main compounds, either singular or synergistic. Thus, further studies are recommended to characterize the major compounds, either alone or in combination as antioxidants or antimicrobial agents, and evaluate their biosafety.
Volatile components of horsetail (Hippuris vulgaris L.) growing in central Italy
Nat Prod Res 2017 Oct;31(19):2316-2320.PMID:28278622DOI:10.1080/14786419.2017.1297936.
Hippuris vulgaris, also known as horsetail or marestail, is a freshwater macrophyte occurring in lakes, rivers, ponds and marshes. According to 'The IUCN Red List of Threatened Species', H. vulgaris is at a high risk of extinction in Italy in the medium-term future. In the present study, we analysed for the first time the volatile composition of H. vulgaris growing in central Italy. For the purpose, the essential oil was obtained by hydrodistillation and analysed by GC-MS. The chemical composition was dominated by aliphatic compounds such as fatty acids (26.0%), ketones (18.7%) and alkanes (11.4%), whereas terpenoids were poorer and mostly represented by diterpenes (7.4%). n-Hexadecanoic acid (25.5%), Hexahydrofarnesyl acetone (17.5%) and trans-phytol (7.4%) were the major volatile constituents. These compounds are here proposed as chemotaxonomic markers of the species.