Hexythiazox
(Synonyms: 噻螨酮) 目录号 : GC39791
An acaricide
Cas No.:78587-05-0
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Hexythiazox is an acaricide that induces toxicity in larvae of the two-spotted spider mite T. urticae and the European red mite P. ulmi (LC50s = 0.15-0.58 and 0.23-0.62 mg AI/L, respectively), as well as in the summer and winter eggs of P. ulmi (LC50s = 2.2 and 20 ppm, respectively).1,2 Hexythiazox is toxic to bluegill (L. macrochirus; LC50 = 3.2 mg/L) and D. magna (EC50 = 0.36 mg/L) but not rats (LD50 = >5,000 mg/kg).3 Formulations containing hexythiazox have been used in the control of mites in agriculture.
1.Nauen, R., Stumpf, N., Elbert, A., et al.Acaricide toxicity and resistance in larvae of different strains of Tetranychus urticae and Panonychus ulmi (Acari: Tetranychidae)Pest Manag. Sci.57(3)(2001) 2.Welty, C., Reissig, W.H., Dennehy, T.J., et al.Susceptibility to hexythiazox of eggs and larvae of european red mite (Acari: Tetranychidae)J. Econ. Entomol.81(2)586-592(1988) 3.Authority, E.F.S.Conclusion on the peer review of the pesticide risk assessment of the active substance hexythiazoxEFSA J.8(10)1722(2010)
| Cas No. | 78587-05-0 | SDF | |
| 别名 | 噻螨酮 | ||
| Canonical SMILES | O=C(N1C(S[C@H](C2=CC=C(Cl)C=C2)[C@H]1C)=O)NC3CCCCC3 | ||
| 分子式 | C17H21ClN2O2S | 分子量 | 352.88 |
| 溶解度 | DMF: 5 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 2 mg/ml,Ethanol: 0.2 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.8338 mL | 14.1691 mL | 28.3382 mL |
| 5 mM | 0.5668 mL | 2.8338 mL | 5.6676 mL |
| 10 mM | 0.2834 mL | 1.4169 mL | 2.8338 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Direct Enantiomeric Separation and Determination of Hexythiazox Enantiomers in Environment and Vegetable by Reverse-Phase High-Performance Liquid Chromatography
Int J Environ Res Public Health 2020 May 15;17(10):3453.PMID:32429166DOI:10.3390/ijerph17103453.
In the present study, the direct enantiomeric separation of Hexythiazox enantiomers on Lux cellulose-1, Lux cellulose-2, Lux cellulose-3, Lux cellulose-4, Lux amylose-1 and Chirapak IC chiral columns were carefully investigated by reverse-phase high-performance liquid chromatography (RP-HPLC). Acetonitrile/water and methanol/water were used as mobile phase at a flow rate of 0.8 mL·min-1. The effects of chiral stationary phase, temperature, thermodynamic parameters, mobile phase component and mobile phase ratio on Hexythiazox enantiomers separation were fully evaluated. Hexythiazox enantiomers received a baseline separation on the Lux cellulose-3 column with a maximum resolution of Rs = 2.09 (methanol/water) and Rs = 2.74 (acetonitrile/water), respectively. Partial separations were achieved on other five chiral columns. Furthermore, Lux amylose-1 and Chirapak IC had no separation ability for Hexythiazox enantiomers when methanol/water was used as mobile phase. Temperature study indicated that the capacity factor (k) and resolution factor (Rs) decreased with column temperature increasing from 10 °C to 40 °C. The enthalpy (ΔH) and entropy (ΔS) involved in Hexythiazox separation were also calculated and demonstrated the lower temperature contributed to better separation resolution. Moreover, the residue analytical method for Hexythiazox enantiomers in the environment (soil and water) and vegetable (cucumber, cabbage and tomato) were also established with reliable accuracy and precision under reverse-phase HPLC condition. Such results provided a baseline separation method for Hexythiazox enantiomers under reverse-phase conditions and contributed to an environmental and health risk assessment of Hexythiazox at enantiomer level.
Transovarial toxicity matters: lethal and sublethal effects of Hexythiazox on the two-spotted spider mite (Acari: Tetranychidae)
Exp Appl Acarol 2022 Jul;87(2-3):175-194.PMID:35867194DOI:10.1007/s10493-022-00733-8.
The effects of Hexythiazox on life-history traits and demographic parameters of Tetranychus urticae Koch (Acari: Tetranychidae) were evaluated using the age-stage two-sex life table (in fecundity-based and fertility-based variants), with emphasis on its transovarial toxicity. Hexythiazox was applied when T. urticae females were either in the preovipositional period or in the first day of oviposition. In the F0 generation bioassay, treatments with concentrations of 50, 12.5 and 3.125 mg/l significantly reduced the longevity of females and their fecundity. These effects were mostly the result of mortality of treated females (18-23%) over the 24-h exposure period. Even though the net reproductive rate (R0) decreased significantly, the intrinsic rate of increase (r), finite rate of increase (λ) and doubling time (D) were not significantly different from the control. The strongest transovarial toxic effect occurred within the first 4 days following treatment, when 52-89% of the eggs laid by treated females (96% in control) hatched. Fertility was significantly reduced by concentrations of 50, 12.5, 3.125, 0.781 and 0.195 mg/l. These concentrations caused significant reductions in R0 (34-54%), r (12-24%) and λ (3-5%), whereas D was extended for 0.4-0.7 days. In the F1 generation bioassay, 50, 12.5, 3.125, 0.781, 0.049 and 0.012 mg/l caused significant reductions in R0 (34-92%), r (10-68%) and λ (3-17%), whereas extending D for 0.3-5.6 days. These effects were mostly the consequence of transovarial toxicity. Application of the fecundity-based life table underestimated population-level effects of Hexythiazox on T. urticae.
Photodegradation of Hexythiazox in different solvent systems under the influence of ultraviolet light and sunlight in the presence of TiO2, H2O2, and KNO3 and identification of the photometabolites
J Agric Food Chem 2011 Nov 9;59(21):11727-34.PMID:21967247DOI:10.1021/jf202144p.
The photodegradation of the carboxamide acaricide Hexythiazox in three different solvent systems (aqueous methanolic, aqueous isopropanolic, and aqueous acetonitrilic solutions) in the presence of H(2)O(2), KNO(3), and TiO(2) under ultraviolet (UV) light (λ(max) ≥ 250 nm) and sunlight (λ(max) ≥290 nm) has been assessed in this work. The kinetics of photodecomposition of Hexythiazox and the identification of photoproducts were carried out using liquid chromatography-mass spectrometry. The rate of photodecomposition of Hexythiazox in different solvents followed first-order kinetics in both UV radiation and natural sunlight, and the degradation rates were faster under UV light than under sunlight. Hexythiazox was found to be more efficiently photodegraded in the presence of TiO(2) than in the presence of H(2)O(2) and KNO(3). Two major photoproducts were separated in pure form using column chromatography and identified according to IR, (1)H NMR, and mass spectral information as cyclohexylamine and 5-(4-chlorophenyl)-4-methylthiazolidin-2-one. Another nine photoproducts were identified according to LC-MS/MS spectral information. The plausible photodegradation pathways of Hexythiazox were proposed according to the structures of the photoproducts.
Resistance to Hexythiazox in Brevipalpus phoenicis (Acari: Tenuipalpidae) from Brazilian citrus
Exp Appl Acarol 2002;26(3-4):243-51.PMID:12537296DOI:10.1023/a:1021103209193.
The objective of this study was to collect baseline information for implementing an acaricide resistance management program of Brevipalpus phoenicis (Geijskes) to Hexythiazox in Brazilian citrus groves. The egg susceptibility of B. phoenicis to Hexythiazox was measured by a direct contact bioassay. The estimated LC50 for the S strain was 0.89 mg Hexythiazox L(-1) of water (95% FL 0.75-1.03). After Hexythiazox selection of a field-collected population associated with intense Hexythiazox use, a resistance ratio greater than 10,000-fold was detected. Results from a survey revealed a great variability in the frequency of resistance in populations of B. phoenicis collected from citrus groves located in the State of São Paulo. No relationship was observed between the intensity of Hexythiazox use and the frequency of resistance. Studies on dynamics of resistance showed that the resistance of B. phoenicis to Hexythiazox is stable under laboratory conditions. Therefore, there is an urgent need to implement resistance management of B. phoenicis to Hexythiazox in order to prolong its effective use in Brazilian citrus groves.
Dissipation dynamic, residue distribution and processing factor of Hexythiazox in strawberry fruits under open field condition
Food Chem 2016 Apr 1;196:1108-16.PMID:26593595DOI:10.1016/j.foodchem.2015.10.052.
Two independent field trials were performed to investigate the dissipation and residue levels of Hexythiazox in strawberry. The study presents a method validation for extraction and quantitative analysis of Hexythiazox residues in strawberry using HPLC-DAD. The results shown that the mean recoveries ranged from 85% to 93%, furthermore the intra- and inter-day relative standard deviations were less than 10%. The results suggest that the Hexythiazox dissipation curves followed the first-order kinetic and its half-life ranged from 3.43 to 3.81 days. The final residues in strawberry were below the Codex maximum residue limit (MRL) (6 mg/kg) after three days of the application. The effects of household processing and storage on the levels of Hexythiazox residues were quantified, and it's useful for reducing the dietary exposure. The processing factor after each stage were generally less than 1, indicating that the whole process can reduce the residues of Hexythiazox in strawberry. The results could provide guidance to safe and reasonable use of Hexythiazox in agriculture.