Histone H3K4Me3 (1-25) amide (human mouse, rat, porcine, bovine) (trifluoroacetate salt)
(Synonyms: ART-K(Me3)-QTARKSTGGKAPRKQLATKAA-NH2, Histone H3 (1-25) (Lys4me3), H3K4me3, Lys(Me3)4-Histone H3 (1-25) amide) 目录号 : GC90304一段组成蛋白质的小分子，来自于组蛋白H3。
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Histone H3K4Me3 (1-25) amide is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-26 of the human histone H3 sequence. Trimetlation of histone H3 at lysine 4 is found in euchromatic promoter regions and is associated with active transcription.1 It inhibits several H3K9 metltransferases and has differential effects on the activities of the KDM7 demetlases PHF8 and KDM7A, activating and inhibiting H3K9Me3 demetlation, respectively. Mislocalization of H3K4Me3 is associated with disease progression and memory deficits in patients with Alzheimer's disease.2
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.3748 mL | 1.874 mL | 3.748 mL |
| 5 mM | 0.075 mL | 0.3748 mL | 0.7496 mL |
| 10 mM | 0.0375 mL | 0.1874 mL | 0.3748 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。