Homocarnosine TFA
(Synonyms: L-Homocarnosine TFA; γ-Aminobutyryl-L-histidine TFA) 目录号 : GC63950
A dipeptide
Cas No.:2991254-59-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Homocarnosine is a dipeptide composed of GABA and L-histidine that has been found in cerebrospinal fluid and the brain.1 It inhibits lipid peroxidation induced by AAPH when used at a concentration of 10 mM.2 Homocarnosine (1 mM) decreases lactate dehydrogenase (LDH) and prostaglandin E2 release from PC12 cells in an in vitro model of ischemia induced by oxygen-glucose deprivation.3 It reduces infarct area and neurological deficit scores in a rat model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).4 Homocarnosine (5 mg/animal) reduces mortality in a mouse model of subcutaneous S. aureus infection.5
1.Crush, K.G.Carnosine and related substances in animal tissuesComp. Biochem. Physiol.34(1)3-30(1970) 2.Kohen, R., Yamamoto, Y., Cundy, K.C., et al.Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brainProc. Natl. Acad. Sci. USA85(9)3175-3179(1988) 3.Tabakman, R., Lazarovici, P., and Kohen, R.Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemiaJ. Neurosci. Res.68(4)463-469(2002) 4.Huang, J., Wang, T., Yu, D., et al.L-Homocarnosine attenuates inflammation in cerebral ischemia-reperfusion injury through inhibition of nod-like receptor protein 3 inflammasomeInt. J. Biol. Macromol.118(Pt A)357-364(2018) 5.Mukkada, A.J., Nutini, L.G., and Cook, E.S.Prophylactic effects of γ-aminobutyrylhistidine (homocarnosine) on experimental staphylococcal infections in miceAppl. Microbiol.18(4)641-645(1969)
| Cas No. | 2991254-59-0 | SDF | Download SDF |
| 别名 | L-Homocarnosine TFA; γ-Aminobutyryl-L-histidine TFA | ||
| 分子式 | C12H17F3N4O5 | 分子量 | 354.28 |
| 溶解度 | Water : 125 mg/mL (352.83 mM; Need ultrasonic) | 储存条件 | Store at -20°C, protect from light, stored under nitrogen |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.8226 mL | 14.1131 mL | 28.2263 mL |
| 5 mM | 0.5645 mL | 2.8226 mL | 5.6453 mL |
| 10 mM | 0.2823 mL | 1.4113 mL | 2.8226 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。