Homogentisic Acid lactone
(Synonyms: Homogentisic Acid γ-lactone,NSC 61996) 目录号 : GC91603Homogentisic acid lactone is a fungal metabolite that has been found in the fungus WF5, has fungicidal activity, and is the lactonized form of homogentisic acid , an intermediate in aromatic amino acid metabolism.
Cas No.:2688-48-4
Sample solution is provided at 25 µL, 10mM.
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Homogentisic acid lactone is a fungal metabolite that has been found in the fungus WF5, has fungicidal activity, and is the lactonized form of homogentisic acid , an intermediate in aromatic amino acid metabolism.[1] It is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone has been used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity and the chemiluminescent detection of HRP release from liposomes.2,3 It is an intermediate in the synthesis of LD-2, a near-infrared probe for the imaging of lipid droplets in live cells.[4]
References:
[1].Mousa, W.K., Schwan, A.L., and Raizada, M.N.Characterization of antifungal natural products isolated from endophytic fungi of finger millet (Eleusine coracana)Molecules21(9)1171(2016).
[2].Bełtowski, J., Wójcicka, G., and Jamroz, A.Leptin decreases plasma paraoxonase 1 (PON1) activity and induces oxidative stress: The possible novel mechanism for proatherogenic effect of chronic hyperleptinemiaAtherosclerosis170(1)21-29(2003).
[3].Kamidate, T., Kikuchi, N., Ishida, A., et al.Determination of peroxidase encapsulated in liposomes using homogentisic acid γ-lactone chemiluminescenceAnal. Sci.21(6)701-704(2005).
[4].Wu, X., Wang, X., Li, Y., et al.A near-infrared probe for specific imaging of lipid droplets in living cellsAnal. Chem.94(11)4881-4888(2022).
| Cas No. | 2688-48-4 | SDF | Download SDF |
| 别名 | Homogentisic Acid γ-lactone,NSC 61996 | ||
| 分子式 | C8H6O3 | 分子量 | 150.1 |
| 溶解度 | DMSO: Soluble: ≥10 mg/ml,Ethanol: Slightly Soluble: 0.1-1 mg/ml | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.6622 mL | 33.3111 mL | 66.6223 mL |
| 5 mM | 1.3324 mL | 6.6622 mL | 13.3245 mL |
| 10 mM | 0.6662 mL | 3.3311 mL | 6.6622 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet