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Hydralazine-d4 (hydrochloride) Sale

(Synonyms: 盐酸肼屈嗪 d4 (盐酸盐)) 目录号 : GC47439

A neuropeptide with diverse biological activities

Hydralazine-d4 (hydrochloride) Chemical Structure

Cas No.:2749234-32-8

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1 mg
¥6,766.00
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Sample solution is provided at 25 µL, 10mM.

Description

Hydralazine-d4 is intended for use as an internal standard for the quantification of hydralazine by GC- or LC-MS. Hydralazine is an orally bioavailable vasodilator and antihypertensive agent.1 It decreases DNA methylation in Jurkat cells at a concentration of 10 μM and inhibits extracellular and intracellular production of reactive oxygen species (ROS) in rat macrophages activated by phorbol 12-myristate 13-acetate at a concentration of 100 μM.2,3 Hydralazine (100 μM) also decreases nitric oxide production and expression of inducible nitric oxide synthase (iNOS) in rat macrophages activated by LPS and interferon-γ (IFN-γ).3 It reduces contraction of rat aortic arterial strips induced by potassium and norepinephrine .4 Hydralazine (2.6 mg/kg) lowers mean arterial blood pressure (MAP) by 41.76% in conscious rats.5 Formulations containing hydralazine have been used in the treatment of high blood pressure and heart failure.

1.Cohn, J.N., McInnes, G.T., and Shepherd, A.M.Direct-acting vasodilatorsJ. Clin. Hypertens. (Greenwich)13(9)690-692(2011) 2.Cornacchia, E., Golbus, J., Maybaum, J., et al.Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivityJ. Immunol.140(7)2197-2200(1988) 3.Leiro, J.M., Alvarez, E., Arranz, J.A., et al.Antioxidant activity and inhibitory effects of hydralazine on inducible NOS/COX-2 gene and protein expression in rat peritoneal macrophagesInt. Immunopharmacol.4(2)163-177(2004) 4.Orallo, F., Gil-Longo, J., BardÁn, B., et al.Comparison of the effects of hydralazine and nifedipine on contractions and 45Ca influx of rat aortaJ. Pharm. Pharmacol.43(5)356-359(1991) 5.Siddiqui, A.A., Mishra, R., Shaharyar, M., et al.Triazole incorporated pyridazinones as a new class of antihypertensive agents: Design, synthesis and in vivo screeningBioorg. Med. Chem. Lett.21(3)1023-1026(2011)

化学性质

Cas No. 2749234-32-8 SDF
别名 盐酸肼屈嗪 d4 (盐酸盐)
Canonical SMILES N/N=C1NN=CC2=C\1C([2H])=C([2H])C([2H])=C2[2H].Cl
分子式 C8H4D4N4.HCl 分子量 200.7
溶解度 DMSO: soluble,Methanol:Water (1:1): soluble 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 4.9826 mL 24.9128 mL 49.8256 mL
5 mM 0.9965 mL 4.9826 mL 9.9651 mL
10 mM 0.4983 mL 2.4913 mL 4.9826 mL
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