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(-)-Hydroxycitric acid

目录号 : GC71452

(-)-Hydroxycitric acid藤黄酸是藤黄果皮的主要酸。

(-)-Hydroxycitric acid Chemical Structure

Cas No.:27750-10-3

规格 价格 库存 购买数量
10mM (in 1mL Water)
¥990.00
现货
1 mg
¥342.00
现货
5 mg
¥900.00
现货
10 mg
¥1,530.00
现货
25 mg
¥3,150.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss.

(-)-Hydroxycitric acid (0-50 µM) reduces lipid droplets accumulation, and decreases ATP-citrate lyase, fatty acid synthase and sterol regulatory element binding protein-1c mRNA level in primary chicken hepatocytes[4].

(-)-Hydroxycitric acid (1.0 mg/kg embryos, injection) reduces lipid droplets accumulation, triglyceride content, lipogenesis factors mRNA level and increases lipolysis factors mRNA expression in chicken embryos[3].
(-)-Hydroxycitric acid (p.o., once) shows a LD50 of greater than 5000 mg/kg in fasted male and female Albino rats[5].
(-)-Hydroxycitric acid (1000-3000 mg/kg diet for 8 weeks) reduces body weight gain, increases feed conversion ratio, and promotes protein synthesis in rats[6].

References:
[1]. B. S. Jena, et al. Chemistry and Biochemistry of (−)-Hydroxycitric Acid from Garcinia. J. Agric. Food Chem. 2002, 50, 1, 10-22.
[2]. Hayamizu K, et al. Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial. Curr Ther Res Clin Exp. 2003 Sep;64(8):551-67.
[3]. Li S, et al. (-)-Hydroxycitric Acid Influenced Fat Metabolism via Modulating of Glucose-6-phosphate Isomerase Expression in Chicken Embryos. J Agric Food Chem. 2019 Jul 3;67(26):7336-7347.
[4]. Li L, et al. (-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes. Cell Physiol Biochem. 2017;43(2):812-831.
[5]. Ohia SE, et al. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem. 2002 Sep;238(1-2):89-103.
[6]. Han N, et al. (-)-Hydroxycitric Acid Nourishes Protein Synthesis via Altering Metabolic Directions of Amino Acids in Male Rats. Phytother Res. 2016 Aug;30(8):1316-29.

Chemical Properties

Cas No. 27750-10-3 SDF
分子式 C6H8O8 分子量 208.12
溶解度 H2O : 5 mg/mL (24.02 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C) 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.8049 mL 24.0246 mL 48.0492 mL
5 mM 0.961 mL 4.8049 mL 9.6098 mL
10 mM 0.4805 mL 2.4025 mL 4.8049 mL
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