Hydroxylupanine
(Synonyms: 13-羟基羽扇豆鹼,Hydroxylupanine) 目录号 : GC47446
An alkaloid
Cas No.:15358-48-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Hydroxylupanine is an alkaloid that has been found in L. lanatus.1 It is an inhibitor of ganglionic transmission.2
1.Neto, A.T., Oliveira, C.Q., Ilha, V., et al.Quinolizidine alkaloids from Lupinus lanatusJ. Mol. Struct.1004(1-3)174-177(2011) 2.Petterson, D.S., Greirson, B.N., Allen, D.G., et al.Disposition of lupanine and 13-hydroxylupanine in manXenobiotica24(9)933-941(1994)
| Cas No. | 15358-48-2 | SDF | |
| 别名 | 13-羟基羽扇豆鹼,Hydroxylupanine | ||
| Canonical SMILES | O=C1CCC[C@@]2([H])N1C[C@]3([H])C[C@@]2([H])CN4[C@@]3([H])C[C@@H](O)CC4 | ||
| 分子式 | C15H24N2O2 | 分子量 | 264.4 |
| 溶解度 | Chloroform: slightly soluble,Methanol: slightly soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.7821 mL | 18.9107 mL | 37.8215 mL |
| 5 mM | 0.7564 mL | 3.7821 mL | 7.5643 mL |
| 10 mM | 0.3782 mL | 1.8911 mL | 3.7821 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
[Lupins - a new source of food for Andean countries. 5. Traditional methods of debittering of lupins by water]
Z Ernahrungswiss 1979 Jul;18(2):104-11.PMID:556411DOI:10.1007/BF02023724.
The bitter taste of lupin alkaloids can be sensorially detected in water within ppm-range. The strength of the taste diminishes as follows: sparteine, D-Lupanin-perchlorate, lupinine, isolupinine and Hydroxylupanine. The swelling capacity of lupin seeds presents different characteristics according to the species. The swelling rapidity is in L. albus somehow inferior to that of L. mutabilis. The absorption of water decreases in hot water, and the swelling rapidity increases. For domestic debittering it is recommended to cook whole lupin seeds during half an hour and to debitter them for 3 days in flowing water. The isoelectric point of the protein of L. mutabilis lies between pH 4 and 4.5.
Alkaloid and predation patterns in colorado lupine populations
Oecologia 1973 Sep;13(3):191-204.PMID:28308576DOI:10.1007/BF00360510.
Colorado populations of herbaceous perennial lupines show three distinct patterns of amounts, kinds, and individual variability of inflorescence alkaloids. These patterns, interpreted as alternative chemical defense strategies, can be related to the susceptibility of populations to attack by larvae of a small flower-feeding lycaenid butterfly, Glaucopsyche lygdamus.In situations ecologically unfavorable to G. lygdumus, lupine populations have "low" alkaloidal profiles, accumulating relatively low amounts of single, bicyclic alkaloids in their inflorescences, with little individual alkaloidal variability, Lupine populations which are quite available to G. lygdamus, on the other hand, accumulate much higher amounts of inflorescence alkaloids. Of these alkaloidally "high" populations, those which suffer only minor predation by G. lygdamus have individually variable mixtures of three or four inflorescence alkaloids, which are found to be isomers of lupanine and closely related tetracyclic compounds. In contrast, those which suffer heavy predation by G. lygdamus show a mixture of nine diverse alkaloidal components including lupanine, Hydroxylupanine, and Hydroxylupanine esters which is quite invariant from individual to individual.It is hypothesized that individual variability in alkaloids is an anti-specialist chemical defense mechanism. Such individual variability may be advantageous to plant populations by reducing the possibility of selection for strains of specialist herbivores capable of detoxifying or otherwise withstanding plant defensive compounds.