Hyperforin (dicyclohexylammonium salt)
(Synonyms: 贯叶金丝桃素二环己基铵盐,Hyp-DCHA, Hyperforin-DCHA) 目录号 : GC43884
A natural compound with diverse actions
Cas No.:238074-03-8
Sample solution is provided at 25 µL, 10mM.
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Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 µg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 µg/ml for CYP2D6).[1],[2] It can also inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50 = 1 µM), 5-lipoxygenase activating protein, and sirtuins.[3],[4],[5]
Reference：
[1]. Wentworth, J.M., Agostini, M., Love, J., et al. St. John’s wort, a herbal antidepressant, activates the steroid X receptor. Journal of Endocrinology 166, R11-R16 (2000).
[2]. Obach, R.S. Inhibition of human cytochrome P450 enzymes by constituents of St. John’s wort, an herbal preparation used in the treatment of depression. Journal of Pharmacology and Experimental Therapeutics 294(1), 88-95 (2000).
[3]. Chang, H.H., and Meuillet, E.J. Identification and development of mPGES-1 inhibitors: Where we are at? Future Med.Chem. 3(15), 1909-1934 (2011).
[4]. Greiner, C., Hörnig, C., Rossi, A., et al. 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52) - a novel type 5-lipoxygenase inhibitor with favorable molecular pharmacology and efficacy in vivo. British Journal of Pharmacology 164(2b), 781-793 (2011).
[5]. Milne, J.C., and Denu, J.M. The sirtuin family:Therapeutic targets to treat diseases of aging. Current Opinion in Chemical Biology 12, 11-17 (2008).
| Cas No. | 238074-03-8 | SDF | |
| 别名 | 贯叶金丝桃素二环己基铵盐,Hyp-DCHA, Hyperforin-DCHA | ||
| 化学名 | (1R,5S,6R,7S)-4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-bicyclo[3.3.1]non-3-ene-2,9-dione, N-cyclohexylcyclohexanamine (1:1) | ||
| Canonical SMILES | O=C1C(C/C=C(C)/C)=C(O)[C@]2(C(C(C)C)=O)[C@@](CC/C=C(C)/C)(C)[C@@H](C/C=C(C)/C)C[C@@]1(C/C=C(C)/C)C2=O.C3(NC4CCCCC4)CCCCC3 | ||
| 分子式 | C35H52O4 • C12H23N | 分子量 | 718.1 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.3926 mL | 6.9628 mL | 13.9256 mL |
| 5 mM | 0.2785 mL | 1.3926 mL | 2.7851 mL |
| 10 mM | 0.1393 mL | 0.6963 mL | 1.3926 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet