IFN b 1b Human
目录号 : GP20393IFN-Beta 1b Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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IFN beta 1b Human Recombinant produced in E.Coli is a single, non-glycosylated mutein (variant form) of human IFN beta-1b polypeptide chain containing 165 amino acids and having a molecular mass of 18510.86 Dalton.The IFN-beta gene was cloned from human fibroblasts and altered to substitute Serine for the Cysteine residue found at position 17. IFN beta-1b is purified by proprietary chromatographic techniques.
| Purity | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | Leukocyte IFN; B cell IFN; Type I IFN; IFNB1; IFB; IFF; IFNB; IFN-b 1b; MGC96956. | ||
| Amino Acid Sequence | The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Tyr-Asn-Leu-Leu. | ||
| Solubility | It is recommended to reconstitute the lyophilized IFN beta-1b in sterile 18M-cm H2O at a concentration of 0.25mg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized IFN-beta 1b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IFNB 1b should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles. | ||
| Biological Activity | The specific activity as determined in a viral resistance assay (human "Wish" cell line and VSV virus or the monkey VERO cell line with EMCV virus) was found to be 32 x 106 IU/mg. | ||
| Formulation | Lyophilized from 1mg/ml solution containing 50mg Human Albumin & 50mg dextrose. | ||
IFN-beta 1b has antiviral, antibacterial and anticancer activities.
The specific activity as determined in a viral resistance assay (human "Wish" cell line and VSV virus or the monkey VERO cell line with EMCV virus) was found to be 32 x 106 IU/mg.
Lyophilized IFN-beta 1b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IFNB 1b should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles.