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IKarisoside A (Icarisoside-A) Sale

(Synonyms: 大花淫羊藿苷 A; Icarisoside-A; Baohuoside II) 目录号 : GC33863

Ikarisoside A (Icarisoside-A) (Icarisoside-A) 是一种天然黄酮醇苷,具有抗炎特性。

IKarisoside A (Icarisoside-A) Chemical Structure

Cas No.:55395-07-8

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥8,402.00
现货
5mg
¥7,631.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

IKarisoside A(Icarisoside-A) is a natural compound isolated from Epimedium koreanum (Berberidaceae); has anti-inflammatory properties.IC50 value:Target: in vitro: Ikarisoside A inhibited the expression of LPS-stimulated inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells and mouse bone marrow-derived macrophages (BMMs) in a concentration-dependent manner. In addition, Ikarisoside A reduced the release of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta). Furthermore, Ikarisoside A inhibited the activity of p38 kinase and nuclear factor-kappaB (NF-kappaB) [1]. Ikarisoside A is a potent inhibitor of osteoclastogenesis in RANKL-stimulated RAW 264.7 cells as well as in bone marrow-derived macrophages.The inhibitory effect of Ikarisoside A resulted in decrease of osteoclast-specific genes like matrix metalloproteinase 9 (MMP9), tartrate-resistant acid phosphatase (TRAP), receptor activator of NF-kappaB (RANK), and cathepsin K. Moreover, Ikarisoside A blocked the resorbing capacity of RAW 264.7 cells on calcium phosphate-coated plates. Ikarisoside A also has inhibitory effects on the RANKL-mediated activation of NF-kappaB, JNK, and Akt [2].

[1]. Choi HJ, et al. Ikarisoside A inhibits inducible nitric oxide synthase in lipopolysaccharide-stimulated RAW 264.7 cells via p38 kinase and nuclear factor-kappaB signaling pathways. Eur J Pharmacol. 2008 Dec 28;601(1-3):171-8. [2]. Choi HJ, eta l. Inhibition of osteoclastogenic differentiation by Ikarisoside A in RAW 264.7 cells via JNK and NF-kappaB signaling pathways. Eur J Pharmacol. 2010 Jun 25;636(1-3):28-35.

化学性质

Cas No. 55395-07-8 SDF
别名 大花淫羊藿苷 A; Icarisoside-A; Baohuoside II
Canonical SMILES OC1=CC(O)=C2C(OC(C3=CC=C(O)C=C3)=C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4O)[C@@H]4O)C2=O)=C1C/C=C(C)\C
分子式 C26H28O10 分子量 500.49
溶解度 Soluble in DMSO 储存条件 4°C, protect from light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.998 mL 9.9902 mL 19.9804 mL
5 mM 0.3996 mL 1.998 mL 3.9961 mL
10 mM 0.1998 mL 0.999 mL 1.998 mL
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