IKK2 Inhibitor VI
(Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide) 目录号 : GC43894An inhibitor of IKK2
Cas No.:354811-10-2
Sample solution is provided at 25 µL, 10mM.
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Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). [1] It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.[2][3]
Reference:
[1]. Baxter, A., Brough, S., Cooper, A., et al. Hit-to-lead studies: The discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorganic & Medicinal Chemistry Letters 14, 2817-2822 (2004).
[2]. McNamara, L.A., Ganesh, J.A., and Collins, K.L. Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation. Journal of Virology 86(17), 9337-9350 (2012).
[3]. Punj, V., Matta, H., and Chaudhary, P.M. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma. PLoS One 7(5), 1-15 (2012).
| Cas No. | 354811-10-2 | SDF | |
| 别名 | 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide | ||
| 化学名 | 2-[(aminocarbonyl)amino]-5-phenyl-3-thiophenecarboxamide | ||
| Canonical SMILES | O=C(N)NC1=C(C(N)=O)C=C(C2=CC=CC=C2)S1 | ||
| 分子式 | C12H11N3O2S | 分子量 | 261.3 |
| 溶解度 | 2mg/mL in ethanol, 30mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.827 mL | 19.1351 mL | 38.2702 mL |
| 5 mM | 0.7654 mL | 3.827 mL | 7.654 mL |
| 10 mM | 0.3827 mL | 1.9135 mL | 3.827 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet