IL 11 Human, Pichia
目录号 : GP20547Interleukin-11 Human Recombinant, Pichia
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. | Source | Pichia Pastoris. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | Interleukin-11; IL-11; Adipogenesis inhibitory factor; AGIF; Oprelvekin; IL11. | ||
| Amino Acid Sequence | The sequence of the first five N-terminal amino acids was determined and was found to be Gly-Pro-Pro-Pro-Gly. | ||
| Solubility | It is recommended to reconstitute the lyophilized Interleukin -11 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized IL11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL11 should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles. | ||
| Biological Activity | The ED50 as determined by the dose-dependent stimulation of the proliferation of murine 7TD1 was found to be less then 0.2ng/ml, corresponding to a Specific Activity of8,000,000 IU/ mg. | ||
| Formulation | IL11 was lyophilized after extensive dialysis against 20mM PB, pH7.0 and 2% Glycine buffer. | ||
IL11 is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). IL-11 is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.
The ED50 as determined by the dose-dependent stimulation of the proliferation of murine 7TD1 was found to be less then 0.2ng/ml, corresponding to a Specific Activity of8,000,000 IU/ mg.
Lyophilized IL11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL11 should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles.