IL 16 Human, (130 a.a.)
目录号 : GP20575Interleukin-16 Human Recombinant, (130 a.a.)
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | IL16; Interleukin-16; LCF; Lymphocyte Chemoattractant Factor; prIL-16; IL-16; FLJ16806; FLJ42735; FLJ44234; HsT19289. | ||
| Amino Acid Sequence | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Pro-Asp-Leu-Asn. | ||
| Solubility | It is recommended to reconstitute the lyophilized Interleukin-16 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized Interleukin-16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL16 should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. | ||
| Biological Activity | The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10-100ng/ml, corresponding to a Specific Activity of 10,000-100,000 units/mg. | ||
| Formulation | IL-16 was lyophilized at 1 mg/ml in 10mM NaP, pH-7.5. | ||
IL-16 is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of IL-16 is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. IL-16 functions exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Two transcript variants encoding different isoforms have been found for this gene.IL-16 stimulates a migratory response in cd4+ lymphocytes, monocytes, and eosinophils. Also induces t-lymphocyte expression of interleukin 2 receptor, ligand for cd4.
The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10-100ng/ml, corresponding to a Specific Activity of 10,000-100,000 units/mg.
Lyophilized Interleukin-16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL16 should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.