il 18 Human
目录号 : GP20603白介素 18 人重组体
Sample solution is provided at 25 µL, 10mM.
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Interleukin-18 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 157 amino acids and having a molecular mass of 18.2 kDa. The IL-18 is purified by proprietary chromatographic techniques.
| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | IGIF; IL-1g; IL-18; IL1F4; MGC12320; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Iboctadekin. | ||
| Solubility | It is recommended to reconstitute the lyophilized Interleukin 18 in sterile PBS at 0.1mg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized Interleukin 18 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL18 should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. | ||
| Biological Activity | The ED50 is 1.5-9 ng/mL and is measured by Interleukin 18 ability to induce IFN-γ secretion by KG‑1 human acute myelogenous leukemia cells in the presence of TNF-alpha. | ||
| Formulation | Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.0. | ||
IL-18 is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.
The ED50 is 1.5-9 ng/mL and is measured by Interleukin 18 ability to induce IFN-γ secretion by KG‑1 human acute myelogenous leukemia cells in the presence of TNF-alpha.
Lyophilized Interleukin 18 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution IL18 should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.